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Carbohydrate Esterase Family 6
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| Carbohydrate Esterase Family CE6 | |
| Fold | ( α / β / α)-sandwich |
| Mechanism | retaining/inverting |
| Active site residues | known/not known |
| CAZy DB link | |
| https://www.cazy.org/CE6.html | |
Substrate specificities
Carbohydrate esterase family 6 (CE6) comprises only acetylxylan esterases (EC 3.1.1.72) - an activity also found in families CE2, CE3, CE4, CE5, CE7, and CE12 [1].
Kinetics and Mechanism
CE6 acetyl xylan esterases target the 2-, 3- or 2,3-linked O-acetyl substituents on the β-1,4-linked xylopyranosyl moieties that comprise the xylan backbone.
Catalytic Residues
Content is to be added here.
Three-dimensional structures
Content is to be added here.
Family Firsts
- First stereochemistry determination
- Content is to be added here.
- First catalytic nucleophile identification
- Content is to be added here.
- First general acid/base residue identification
- Content is to be added here.
- First 3-D structure
- Arabidopsis thaliana apo acetyl xylan esterase in 2005 PDB ID 2APJ [2].
References
- Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, and Henrissat B. (2009). The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics. Nucleic Acids Res. 2009;37(Database issue):D233-8. DOI:10.1093/nar/gkn663 |
- Bitto E, Bingman CA, McCoy JG, Allard ST, Wesenberg GE, and Phillips GN Jr. (2005). The structure at 1.6 Angstroms resolution of the protein product of the At4g34215 gene from Arabidopsis thaliana. Acta Crystallogr D Biol Crystallogr. 2005;61(Pt 12):1655-61. DOI:10.1107/S0907444905034074 |
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Davies, G.J. and Sinnott, M.L. (2008) Sorting the diverse: the sequence-based classifications of carbohydrate-active enzymes. The Biochemist, vol. 30, no. 4., pp. 26-32. Download PDF version.