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'''25 November 2021''' ''CRO about it!:'' In our latest [[Curator Approved]] page in a while, '''[[User:Maria Cleveland|Maria Cleveland]]''' has written an extensive history of the Copper Radical Oxidases (CROs) that constitute '''[[Auxiliary Activity Family 5]]'''. The archetypal '''[[AA5]]''' CRO is the ''Fusarium graminearum'' galactose oxidase, which was first isolated in the 1950s, provided the first 3-D structure in the 1990s, and has been the subject of numerous mechanistic studies up through the new millennium. '''[[AA5]]''' also contains the glyoxal oxidases, which were discovered in Wisconsin in the late 1980s and form their own subfamily. More recent work by [[User:Maria Cleveland|Maria Cleveland]], [[User:Yann Mathieu|Yann Mathieu]], and others has shown that a wider range of substrate specificities exists in this family than previously anticipated, while the catalytic flexibility of wild-type and mutant enzymes has spurred numerous biotech applications. ''Slide on over to the '''[[AA5]]''' page, which includes a <u>deep</u> reference list, to learn more about these interesting enzymes!'' | '''25 November 2021''' ''CRO about it!:'' In our latest [[Curator Approved]] page in a while, '''[[User:Maria Cleveland|Maria Cleveland]]''' has written an extensive history of the Copper Radical Oxidases (CROs) that constitute '''[[Auxiliary Activity Family 5]]'''. The archetypal '''[[AA5]]''' CRO is the ''Fusarium graminearum'' galactose oxidase, which was first isolated in the 1950s, provided the first 3-D structure in the 1990s, and has been the subject of numerous mechanistic studies up through the new millennium. '''[[AA5]]''' also contains the glyoxal oxidases, which were discovered in Wisconsin in the late 1980s and form their own subfamily. More recent work by [[User:Maria Cleveland|Maria Cleveland]], [[User:Yann Mathieu|Yann Mathieu]], and others has shown that a wider range of substrate specificities exists in this family than previously anticipated, while the catalytic flexibility of wild-type and mutant enzymes has spurred numerous biotech applications. ''Slide on over to the '''[[AA5]]''' page, which includes a <u>deep</u> reference list, to learn more about these interesting enzymes!'' | ||
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'''23 June 2021''' ''A free CAZypedia webinar:'' Check out the presentation on ''CAZypedia'' by [[Board of Curators|Senior Curator]] [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]], which was part of a webinar on Recent Advances in Carbohydrate-Active Enzymes organized by [[User:Stefan Janecek|Stefan Janecek]]. [[User:Stefan Janecek|Stefan]] also gave a talk on alpha-amylase bioinformatics, and Nicolas Terrapon gave an overview of the [http://www.cazy.org/ CAZy database] in a presentation entitled "Carbohydrate-Active EnZymes Annotation in the High-Throughput Era". ''More information on the webinar can be found [https://molecules-12.sciforum.net/ here], and you can [https://youtu.be/JyV-zkr8Jw4 watch all three lectures for free on YouTube].'' | '''23 June 2021''' ''A free CAZypedia webinar:'' Check out the presentation on ''CAZypedia'' by [[Board of Curators|Senior Curator]] [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]], which was part of a webinar on Recent Advances in Carbohydrate-Active Enzymes organized by [[User:Stefan Janecek|Stefan Janecek]]. [[User:Stefan Janecek|Stefan]] also gave a talk on alpha-amylase bioinformatics, and Nicolas Terrapon gave an overview of the [http://www.cazy.org/ CAZy database] in a presentation entitled "Carbohydrate-Active EnZymes Annotation in the High-Throughput Era". ''More information on the webinar can be found [https://molecules-12.sciforum.net/ here], and you can [https://youtu.be/JyV-zkr8Jw4 watch all three lectures for free on YouTube].'' | ||
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'''31 May 2021''' ''Celebrating CAZy:'' The [[B.A. Stone Award for Excellence in Plant Polysaccharide Biochemistry]] was awarded to [http://www.cazy.org/ CAZy] founder [[User:Bernard Henrissat|Bernard Henrissat]] today. CAZy, ''CAZypedia'', and [[Bruce Stone|Prof. Bruce Stone]] have a [[CAZypedia:History|long, intertwined history]], and today we celebrate [[User:Bernard Henrissat|Bernie's]] insight to create a [https://doi.org/10.1042/BIO03004026 sequence-based classification of the Carbohydrate-Active EnZymes], [https://doi.org/10.1016/0378-1119(89)90339-9 starting with the cellulases]. | '''31 May 2021''' ''Celebrating CAZy:'' The [[B.A. Stone Award for Excellence in Plant Polysaccharide Biochemistry]] was awarded to [http://www.cazy.org/ CAZy] founder [[User:Bernard Henrissat|Bernard Henrissat]] today. CAZy, ''CAZypedia'', and [[Bruce Stone|Prof. Bruce Stone]] have a [[CAZypedia:History|long, intertwined history]], and today we celebrate [[User:Bernard Henrissat|Bernie's]] insight to create a [https://doi.org/10.1042/BIO03004026 sequence-based classification of the Carbohydrate-Active EnZymes], [https://doi.org/10.1016/0378-1119(89)90339-9 starting with the cellulases]. | ||
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Revision as of 17:13, 25 November 2021
25 November 2021 CRO about it!: In our latest Curator Approved page in a while, Maria Cleveland has written an extensive history of the Copper Radical Oxidases (CROs) that constitute Auxiliary Activity Family 5. The archetypal AA5 CRO is the Fusarium graminearum galactose oxidase, which was first isolated in the 1950s, provided the first 3-D structure in the 1990s, and has been the subject of numerous mechanistic studies up through the new millennium. AA5 also contains the glyoxal oxidases, which were discovered in Wisconsin in the late 1980s and form their own subfamily. More recent work by Maria Cleveland, Yann Mathieu, and others has shown that a wider range of substrate specificities exists in this family than previously anticipated, while the catalytic flexibility of wild-type and mutant enzymes has spurred numerous biotech applications. Slide on over to the AA5 page, which includes a deep reference list, to learn more about these interesting enzymes!
23 June 2021 A free CAZypedia webinar: Check out the presentation on CAZypedia by Senior Curator Elizabeth Ficko-Blean, which was part of a webinar on Recent Advances in Carbohydrate-Active Enzymes organized by Stefan Janecek. Stefan also gave a talk on alpha-amylase bioinformatics, and Nicolas Terrapon gave an overview of the CAZy database in a presentation entitled "Carbohydrate-Active EnZymes Annotation in the High-Throughput Era". More information on the webinar can be found here, and you can watch all three lectures for free on YouTube.
31 May 2021 Celebrating CAZy: The B.A. Stone Award for Excellence in Plant Polysaccharide Biochemistry was awarded to CAZy founder Bernard Henrissat today. CAZy, CAZypedia, and Prof. Bruce Stone have a long, intertwined history, and today we celebrate Bernie's insight to create a sequence-based classification of the Carbohydrate-Active EnZymes, starting with the cellulases.