User:Tirso Pons

Tirso Pons obtained his B.Sc. degree in Nuclear Physics from the Institute of Nuclear Sciences, Havana, then completed his Ph.D. in Biology at University of Havana with Joaquin Diaz and Alfonso Valencia in 2002, working on the sequence analysis, and structure and functional residues prediction for glycoside hydrolase GH32, GH49 and GH68 families. He and colleagues predicted for the first time a common beta-propeller fold for the catalytic domain in GH32 and GH68 families, and also proposed the aspartate residue in the conserved "Arg-Asp-Pro (RDP) motif" as a third residue important for catalysis. Through collaboration with Prof. Gideon Davies (York University, UK), he and colleagues determined the crystal structure of levansucrase from the gram-negative bacterium Gluconacetobacter diazotrophicus SRT4. Tirso was a visiting scientist at Dr. Alfonso Valencia's Lab (CNB-CSIC) at the Autonomous University of Madrid, Spain, and at Dr. Gert Vriend's lab at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. In 2007 and 2010 he obtained postdoctoral SEBiot and EMBO fellowships at the Structural Biology and Biocomputing Programme of the Spanish National Cancer Research Centre (CNIO), Madrid. From 2006 to 2011, he was an Associate Professor at Deparment of Biochemistry, and permanent researcher at the Center for Protein Research (CEP), Faculty of Biology, University of Havana. He is currently a staff scientists in the Structural Computational Biology Group within the Structural Biology and Biocomputing Programme at CNIO. More details are available at the web sites [1] or [2]