CAZypedia needs your help!
We have many unassigned pages in need of Authors and Responsible Curators. See a page that's out-of-date and just needs a touch-up? - You are also welcome to become a CAZypedian. Here's how.
Scientists at all career stages, including students, are welcome to contribute.
Learn more about CAZypedia's misson here and in this article.
Totally new to the CAZy classification? Read this first.
Difference between revisions of "User:John Samuelson"
Harry Brumer (talk | contribs) (Created page with "200px|right '''This is an empty template to help you get started with composing your User page.''' You should begin by opening this page for ed...") |
Harry Brumer (talk | contribs) m (Text replacement - "\^\^\^(.*)\^\^\^" to "$1") |
||
| (6 intermediate revisions by one other user not shown) | |||
| Line 1: | Line 1: | ||
| − | [[ | + | [[File:Samuelson.jpg|200px|right]] |
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| + | John Samuelson received his M.D. and Ph.D. in Cell and Developmental Biology from Harvard Medical School. As a post-doctoral fellow and faculty member at the Harvard School of Public Health, he discovered extensive horizontal gene transfer from bacteria and a cryptic mitochondrion-derived organelle in ''Entamoeba histolytica'', the protist that causes dysentery and liver abscess. With his move to Boston University, Dr. Samuelson got his real introduction to glycobiology in a 15 year collaboration with Phil Robbins. Together they showed the major cyst wall proteins of ''Entamoeba'' are chitin-binding lectins and identified [[CBM55]] at the N-terminus of the chitinase <cite>Frisardi2000,VanDellen2002,Chatterjee2009 </cite>. They showed that the most abundant cyst wall proteins of ''Giardia lamblia'', cause of diarrhea, have Leu-rich repeats that bind to fibrils of the unique β-1,3-linked GalNAc polymer <cite>Chatterjee2010</cite>. They demonstrated β-1,3-glucan in the inner layer of the oocyst wall of ''Toxoplasma gondii'', cause of birth defects, and identified a unique glucan-binding domain at the N-terminus of the [[GH17]] glycoside hydrolase <cite>Bushkin2012</cite>. In a separate line of experiments, Drs. Samuelson and Robbins showed that secondary loss of genes encoding Alg enzymes explains the diversity of N-glycan precursors among eukaryotes <cite>Samuelson2005</cite>, demonstrated Darwinian selection for N-glycan sites in secreted proteins of the vast majority of eukaryotes that have N-glycan-dependent quality control of glycoprotein folding in the ER lumen <cite>Cui2009</cite>, and identified N-glycans of ''Entamoeba'', ''Giardia'', and ''Plasmodium falciparum'' (cause of malaria) <cite>Magnelli2008,Ratner2008,Bushkin2010</cite>. With Giulia Bandini they discovered a large set of nuclear proteins of ''Toxoplasma'' that are decorated with O-linked fucose <cite>Bandini2016</cite> and with Chris West showed that the O-fucosyltransferase is a homolog of plant Spindly, which contains TPR and [[GT41]] domains <cite>Gas-Pascual2019</cite>. Recently, Dr. Samuelson with [[User:Breeanna Urbanowicz|Breeanna Urbanowicz]] showed the most abundant proteins in the cyst wall of ''Acanthamoeba castellanii'', cause of blindness, are cellulose- and chitin-binding lectins <cite>Magistrado-Coxen2019</cite>. | ||
---- | ---- | ||
<biblio> | <biblio> | ||
| − | # | + | #Frisardi2000 pmid=10858239 |
| + | #VanDellen2002 pmid=12011021 | ||
| + | #Chatterjee2009 pmid=19578434 | ||
| + | #Chatterjee2010 pmid=20808847 | ||
| + | #Bushkin2012 pmid=23015739 | ||
| + | #Samuelson2005 pmid=15665075 | ||
| + | #Cui2009 pmid=19666543 | ||
| + | #Magnelli2008 pmid=18417475 | ||
| + | #Ratner2008 pmid=18820077 | ||
| + | #Bushkin2010 pmid=19783771 | ||
| + | #Bandini2016 pmid=27663739 | ||
| + | #Gas-Pascual2019 pmid=30463938 | ||
| + | #Magistrado-Coxen2019 pmid=31095564 | ||
</biblio> | </biblio> | ||
Latest revision as of 13:35, 18 December 2021
John Samuelson received his M.D. and Ph.D. in Cell and Developmental Biology from Harvard Medical School. As a post-doctoral fellow and faculty member at the Harvard School of Public Health, he discovered extensive horizontal gene transfer from bacteria and a cryptic mitochondrion-derived organelle in Entamoeba histolytica, the protist that causes dysentery and liver abscess. With his move to Boston University, Dr. Samuelson got his real introduction to glycobiology in a 15 year collaboration with Phil Robbins. Together they showed the major cyst wall proteins of Entamoeba are chitin-binding lectins and identified CBM55 at the N-terminus of the chitinase [1, 2, 3]. They showed that the most abundant cyst wall proteins of Giardia lamblia, cause of diarrhea, have Leu-rich repeats that bind to fibrils of the unique β-1,3-linked GalNAc polymer [4]. They demonstrated β-1,3-glucan in the inner layer of the oocyst wall of Toxoplasma gondii, cause of birth defects, and identified a unique glucan-binding domain at the N-terminus of the GH17 glycoside hydrolase [5]. In a separate line of experiments, Drs. Samuelson and Robbins showed that secondary loss of genes encoding Alg enzymes explains the diversity of N-glycan precursors among eukaryotes [6], demonstrated Darwinian selection for N-glycan sites in secreted proteins of the vast majority of eukaryotes that have N-glycan-dependent quality control of glycoprotein folding in the ER lumen [7], and identified N-glycans of Entamoeba, Giardia, and Plasmodium falciparum (cause of malaria) [8, 9, 10]. With Giulia Bandini they discovered a large set of nuclear proteins of Toxoplasma that are decorated with O-linked fucose [11] and with Chris West showed that the O-fucosyltransferase is a homolog of plant Spindly, which contains TPR and GT41 domains [12]. Recently, Dr. Samuelson with Breeanna Urbanowicz showed the most abundant proteins in the cyst wall of Acanthamoeba castellanii, cause of blindness, are cellulose- and chitin-binding lectins [13].
Error fetching PMID 12011021:
Error fetching PMID 19578434:
Error fetching PMID 20808847:
Error fetching PMID 23015739:
Error fetching PMID 15665075:
Error fetching PMID 19666543:
Error fetching PMID 18417475:
Error fetching PMID 18820077:
Error fetching PMID 19783771:
Error fetching PMID 27663739:
Error fetching PMID 30463938:
Error fetching PMID 31095564:
- Error fetching PMID 10858239:
- Error fetching PMID 12011021:
- Error fetching PMID 19578434:
- Error fetching PMID 20808847:
- Error fetching PMID 23015739:
- Error fetching PMID 15665075:
- Error fetching PMID 19666543:
- Error fetching PMID 18417475:
- Error fetching PMID 18820077:
- Error fetching PMID 19783771:
- Error fetching PMID 27663739:
- Error fetching PMID 30463938:
- Error fetching PMID 31095564: