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Difference between revisions of "Template:News"

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'''27 February 2016:''' ''The sweet side of sulfur:'' '''[[User:Spencer Williams|Spencer Williams]]''' has updated the [[Glycoside Hydrolase Family 31]] page to reflect the recent discovery of the first dedicated sulfoquinovosidases (SQases), previously ‘hidden’ within this family. SQases cleave alpha-glycosides of sulfoquinovose (6-sulfoglucose), which represent a significant reservoir of organosulfur in the biosphere. ''See the [[GH31]] page to discover more of the hidden charms of this family.''
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'''19 July 2024:''' ''Chalk-up one more for the GTs!'' The '''[[Glycosyltransferase Family 47]]''' page joined the small group of [[Curator Approved]] [[Glycosyltransferase Families]] pages in ''CAZypedia'' today. This entry was [[author]]ed by Ph.D. students '''[[User:Daniel Tehrani|Daniel Tehrani]]''' and '''[[User:Charlie Corulli|Charlie Corulli]]''', and [[Responsible Curator|Curated]] by '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' with input from '''[https://ccrc.uga.edu/team/kelley-moremen/ Kelley Moremen]'''.  Widely represented in plants, '''[[GT47]]''' members are anomer-[[inverting]] [[glycosyltransferases]], which are involved in the biosynthesis of several cell wall matrix polysaccharides.  Representatives from mammals are involved in heparin biosynthesis. Correspondingly, members of [[GH47]] have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides.  ''This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!''
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'''9 July 2024:''' ''Yet another new family of beta-1,2-glucan-active enzymes!'' Today, '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''' [[Curator Approved]] the '''[[Glycoside Hydrolase Family 186]]''' page by '''[[User:Sei Motouchi|Sei Motouchi]]'''. '''[[GH186]]''' is a family of anomer-[[inverting]] enzymes from bacteria, members of which are specific for beta-1,2-glucans.  Intriguingly, although some [[GH186]] members work as classic [[glycoside hydrolases]], others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack.  Also notable, [[GH186]] members appear to use an extended chain of water molecules to relay acceptor deprotonation by the [[general base]] residue, ''i.e.'' a [https://en.wikipedia.org/wiki/Grotthuss_mechanism Grotthuss mechanism]. ''Check out the '''[[GH186]]''' page to learn more about these interesting enzymes, and make sure to see the [[GH189]], [[GH144]], and [[GH162]] pages from this same group.''
  
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'''11 September 2015:''' ''Let's hear it for the [[transglycosylases]]!:''  Today, [[Author]]s '''[[User:Ramon Hurtado-Guerrero|Ramon Hurtado-Guerrero]]''' and '''[[User:Thierry Fontaine|Thierry Fontaine]]''', together with [[Responsible Curator]]  '''[[User:Bernard Henrissat|Bernard Henrissat]]''', completed the '''[[Glycoside Hydrolase Family 72]]''' page.  '''[[GH72]]''' is a small but important family of beta(1-3)-glucan [[transglycosylases]] that function to remodel the cell wall during the growth of yeast and other fungi.  Predominant or strict transglycosylases are relatively rare in GH families, with other notable examples coming from [[GH13]], [[GH16]], [[GH31]], [[GH70]], and [[GH77]]. ''Read more about '''[[GH72]]''' and what makes [[transglycosylases]] so interesting here in CAZypedia!''
 
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'''6 August 2015:'''  ''Live from the Cellulase/CAZyme GRC:''  ''CAZypedia'' marches on with the completion of the '''[[Polysaccharide Lyase Family 1]]''' today by [[Responsible Curator]] and [[Author]] '''[[User:Richard Pickersgill|Richard Pickersgill]]''', with additional editing by [[Polysaccharide Lyase Families]] coordinator '''[[User:Wade Abbott|Wade Abbott]]'''.  '''[[PL1]]''' contains pectate lyases from microbes and plants, which are key enzymes in plant cell wall remodelling/break-down.  The solution of the crystal structure of a pectate lyase C from the plant pathogen ''Erwinia chrysanthemi'' was the first to reveal the parallel beta-helix as a novel protein fold that is now known to serve as the scaffold of other pectinolytic enzymes, including pectin hydrolases ([[GH28]]) and pectin methylesterases ([http://www.cazy.org/CE8.html CE8]).  ''Read more about the discovery of pectate lyases and the enzymology and crystallography of [[PL1]] [[PL1|here]].''
 
 
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'''28 July 2015:''' '''''100 GH FAMILIES!!!''''' We are extremely pleased to announce that ''CAZypedia'' has reached the key milestone of 100 [[Curator Approved]] [[Glycoside Hydrolase Families|Glycoside Hydrolase Family]] pages today, thanks to the completion of the '''[[Glycoside Hydrolase Family 12]]''' page by '''[[User:Gerlind Sulzenbacher|Gerlind Sulzenbacher]]'''.  '''[[GH12]]''' is one of the classic "cellulase" families ([http://www.ncbi.nlm.nih.gov/pubmed/1886523?dopt=Abstract formerly known as cellulase family H]) defined early in the history of the CAZy classification; [[GH12]] is now known to comprise both microbial endo-glucanases and endo-xyloglucanases.  The completion of this page is especially timely in advance of the upcoming [http://www.grc.org/programs.aspx?id=12846 2015 GRC on Cellulosomes, Cellulases & Other Carbohydrate Modifying Enzymes], happening next week. [[User:Gerlind Sulzenbacher|Gerlind]] performed the seminal crystallography in this family (under the mentorship of [[User:Gideon Davies|Gideon Davies]]), and we would especially like to thank her for producing an excellent summary and series of figures for the "[[Glycoside_Hydrolase_Family_12#Three-dimensional_structures|Three-dimensional structures]]" section.
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'''2 May 2024:''' ''CBDs I to X... A major milestone!'' '''CBM families 1 to 10 are now complete!''' These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective ''CAZypedia'' pages: '''[[CBM1]], [[CBM2]], [[CBM3]], [[CBM4]], [[CBM5]], [[CBM6]], [[CBM7]], [[CBM8]], [[CBM9]], and [[CBM10]]'''.
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''The [[Board of Curators]] would also like to take the opportunity of this key milestone to express our sincere gratitude to our many expert [[:Category:Contributors|Contributors]] for their time and dedication to building ''CAZypedia'' as a community-based resource [[:CAZypedia:History|over the past 8 years]]. In addition to the [[Glycoside Hydrolase Families|100 Curator Approved GH pages]], ''CAZypedia'' also currently contains [[Polysaccharide_Lyase_Families|5 PL Family pages]], [[Auxiliary Activity Families|2 AA Family pages]], [[Glycosyltransferase Families|2 GT Family pages]], [[Carbohydrate Binding Module Families|10 CBM Family pages]], and [[Lexicon|22 Lexicon pages]]!''
 
 
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Latest revision as of 09:56, 22 July 2024

19 July 2024: Chalk-up one more for the GTs! The Glycosyltransferase Family 47 page joined the small group of Curator Approved Glycosyltransferase Families pages in CAZypedia today. This entry was authored by Ph.D. students Daniel Tehrani and Charlie Corulli, and Curated by Breeanna Urbanowicz with input from Kelley Moremen. Widely represented in plants, GT47 members are anomer-inverting glycosyltransferases, which are involved in the biosynthesis of several cell wall matrix polysaccharides. Representatives from mammals are involved in heparin biosynthesis. Correspondingly, members of GH47 have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides. This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!

9 July 2024: Yet another new family of beta-1,2-glucan-active enzymes! Today, Masahiro Nakajima Curator Approved the Glycoside Hydrolase Family 186 page by Sei Motouchi. GH186 is a family of anomer-inverting enzymes from bacteria, members of which are specific for beta-1,2-glucans. Intriguingly, although some GH186 members work as classic glycoside hydrolases, others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack. Also notable, GH186 members appear to use an extended chain of water molecules to relay acceptor deprotonation by the general base residue, i.e. a Grotthuss mechanism. Check out the GH186 page to learn more about these interesting enzymes, and make sure to see the GH189, GH144, and GH162 pages from this same group.

2 May 2024: CBDs I to X... A major milestone! CBM families 1 to 10 are now complete! These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective CAZypedia pages: CBM1, CBM2, CBM3, CBM4, CBM5, CBM6, CBM7, CBM8, CBM9, and CBM10.

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