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Difference between revisions of "Template:News"

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'''25 November 2021''' ''CRO about it!:'' In our latest [[Curator Approved]] page in a while, '''[[User:Maria Cleveland|Maria Cleveland]]''' has written an extensive history of the Copper Radical Oxidases (CROs) that constitute '''[[Auxiliary Activity Family 5]]'''.  The archetypal '''[[AA5]]''' CRO is the ''Fusarium graminearum galactose oxidase, which was first isolated in the 1950s, provided the first 3-D structure in the 1990s, and has been the subject of numerous mechanistic studies up through the new millennium.  '''[[AA5]]''' also contains the glyoxal oxidases, which were discovered in Wisconsin in the late 1980s and form their own subfamily. More recent work by [[User:Maria Cleveland|Maria Cleveland]], [[User:Yann Mathieu|Yann Mathieu]], and others has shown that a wider range of substrate specificities exists in this family than previously anticipated, while the catalytic flexibility of wild-type and mutant enzymes has spurred numerous biotech applications. ''Slide on over to the '''[[AA5]]''' page, which includes a deep reference list, to learn more about these interesting enzymes!''
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'''19 July 2024:''' ''Chalk-up one more for the GTs!'' The '''[[Glycosyltransferase Family 47]]''' page joined the small group of [[Curator Approved]] [[Glycosyltransferase Families]] pages in ''CAZypedia'' today. This entry was [[author]]ed by Ph.D. students '''[[User:Daniel Tehrani|Daniel Tehrani]]''' and '''[[User:Charlie Corulli|Charlie Corulli]]''', and [[Responsible Curator|Curated]] by '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' with input from '''[https://ccrc.uga.edu/team/kelley-moremen/ Kelley Moremen]'''.  Widely represented in plants, '''[[GT47]]''' members are anomer-[[inverting]] [[glycosyltransferases]], which are involved in the biosynthesis of several cell wall matrix polysaccharides.  Representatives from mammals are involved in heparin biosynthesis. Correspondingly, members of [[GH47]] have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides. ''This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!''
 
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'''9 July 2024:''' ''Yet another new family of beta-1,2-glucan-active enzymes!'' Today, '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''' [[Curator Approved]] the '''[[Glycoside Hydrolase Family 186]]''' page by '''[[User:Sei Motouchi|Sei Motouchi]]'''. '''[[GH186]]''' is a family of anomer-[[inverting]] enzymes from bacteria, members of which are specific for beta-1,2-glucans.  Intriguingly, although some [[GH186]] members work as classic [[glycoside hydrolases]], others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack.  Also notable, [[GH186]] members appear to use an extended chain of water molecules to relay acceptor deprotonation by the [[general base]] residue, ''i.e.'' a [https://en.wikipedia.org/wiki/Grotthuss_mechanism Grotthuss mechanism]. ''Check out the '''[[GH186]]''' page to learn more about these interesting enzymes, and make sure to see the [[GH189]], [[GH144]], and [[GH162]] pages from this same group.''
  
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'''23 June 2021''' ''A free CAZypedia webinar:'' Check out the presentation on ''CAZypedia'' by [[Board of Curators|Senior Curator]] [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]], which was part of a webinar on Recent Advances in Carbohydrate-Active Enzymes organized by [[User:Stefan Janecek|Stefan Janecek]].  [[User:Stefan Janecek|Stefan]] also gave a talk on alpha-amylase bioinformatics, and Nicolas Terrapon gave an overview of the [http://www.cazy.org/ CAZy database] in a presentation entitled "Carbohydrate-Active EnZymes Annotation in the High-Throughput Era".  ''More information on the webinar can be found [https://molecules-12.sciforum.net/ here], and you can [https://youtu.be/JyV-zkr8Jw4 watch all three lectures for free on YouTube].''
 
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'''31 May 2021''' ''Celebrating CAZy:'' The [[B.A. Stone Award for Excellence in Plant Polysaccharide Biochemistry]] was awarded to [http://www.cazy.org/ CAZy] founder [[User:Bernard Henrissat|Bernard Henrissat]] today.  CAZy, ''CAZypedia'', and [[Bruce Stone|Prof. Bruce Stone]] have a [[CAZypedia:History|long, intertwined history]], and today we celebrate [[User:Bernard Henrissat|Bernie's]] insight to create a [https://doi.org/10.1042/BIO03004026 sequence-based classification of the Carbohydrate-Active EnZymes], [https://doi.org/10.1016/0378-1119(89)90339-9 starting with the cellulases].
 
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'''30 March 2021''' ''Presenting the gagalicious [[CBM87]] family:'' [[CBM87]] members are found appended to [[CE18|fungal galactosaminogalactan deacetylases]] that are involved in biofilm formation.  The [[CBM87]]s have the unusual - but not unheard of - property of extending the enzyme's catalytic site.  The GAG-binding [[CBM87]] CAZypedia page has been authored by '''[[User:Natalie Bamford|Natalie Bamford]]''' with  [[User:Lynne Howell|Lynne Howell]] acting as responsible curator.  ''Go gaga for the GAG-binding [[CBM87]] family [[CBM87|here]].''
 
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'''2 December 2020:''' ''It's a bird, it's a plane, it's [[CBM14]]!'' From start to finish in superhero time, the lectin-containing, chitin-binding [[CBM14]] page is up and running. This is thanks to the heroic efforts of author '''[[User:Eva Madland|Eva Madland]]''' with  [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]] acting as responsible curator for the [[CBM14]] page.  [[CBM14|This]] CBM family continues to blur the lines betweeen CBMs and lectins and even type [[Carbohydrate-binding_modules#Types|A]] , [[Carbohydrate-binding_modules#Types|B]]  and  [[Carbohydrate-binding_modules#Types|C]] CBMs. ''Find out more on these interesting chitin-binding multi-characteristic CBMs [[CBM14|here]].''
 
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'''1 December 2020:'''  ''YANCEFP! (<u>Y</u>et <u>A</u>nother <u>N</u>ew <u>C</u>arbohydrate <u>E</u>sterase <u>F</u>amily <u>P</u>age, from our friends at WLU!'') Following on a string of CE pages completed by students at Wilfred Laurier University (see [[CE3]], [[CE4]], [[CE7]] and [[CE9]]), today '''[[User:Bobby Lamont|Bobby Lamont]]''' finalized the  '''[[Carbohydrate Esterase Family 2]]''' under the guidance of '''[[User:Joel Weadge|Prof. Joel Weadge]]''' and '''[[User:Anthony Clarke|Prof. Anthony Clarke]]'''.  '''[[CE2]]''' contains carbohydrate de-''O''-acetylases with diverse regiospecifcity, which use a catalytic dyad to perform hydrolysis.  ''This family has a long and rich history of mechanistic and structural study, dating back to the last millennium, which you can learn much more about [[Carbohydrate Esterase Family 2|on Bobby's detailed page]].''
 
 
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'''29 September 2020:''' ''Back to the future with beta-1,3-glucanases:'' The '''[[Glycoside Hydrolase Family 128]]''' page was promoted to [[Curator Approved]] status by '''[[User:Mario Murakami|Mario Murakami]]''' today. '''[[GH128]]''' was originally created following the discovery of this family by '''[[User:Yuichi Sakamoto|Yuichi Sakamoto]]''' and colleagues, who characterized the archetypal beta-1,3-glucanase from the  shiitake mushroom. This year, a team led by '''[[User:Mario Murakami|Mario Murakami]]''', including first-author '''[[User:Camila Santos|Camila Santos]]''', presented a sweeping first mechanistic and structural study of '''[[GH128]]'''.  ''We're grateful to '''[[User:Camila Santos|Camila]]''' and '''[[User:Mario Murakami|Mario]]''' for elaborating upon '''[[User:Yuichi Sakamoto|Yuichi's]]''' original CAZypedia page, which you can read [[Glycoside Hydrolase Family 128|here]]. You can also compare '''[[GH128]]''' with other distinct beta-1,3-glucanase families covered in CAZypedia, e.g. [[GH17]], [[GH81]], [[GH148]], and [[GH158]].''
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'''2 May 2024:''' ''CBDs I to X... A major milestone!'' '''CBM families 1 to 10 are now complete!''' These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective ''CAZypedia'' pages: '''[[CBM1]], [[CBM2]], [[CBM3]], [[CBM4]], [[CBM5]], [[CBM6]], [[CBM7]], [[CBM8]], [[CBM9]], and [[CBM10]]'''.
 
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Latest revision as of 09:56, 22 July 2024

19 July 2024: Chalk-up one more for the GTs! The Glycosyltransferase Family 47 page joined the small group of Curator Approved Glycosyltransferase Families pages in CAZypedia today. This entry was authored by Ph.D. students Daniel Tehrani and Charlie Corulli, and Curated by Breeanna Urbanowicz with input from Kelley Moremen. Widely represented in plants, GT47 members are anomer-inverting glycosyltransferases, which are involved in the biosynthesis of several cell wall matrix polysaccharides. Representatives from mammals are involved in heparin biosynthesis. Correspondingly, members of GH47 have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides. This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!

9 July 2024: Yet another new family of beta-1,2-glucan-active enzymes! Today, Masahiro Nakajima Curator Approved the Glycoside Hydrolase Family 186 page by Sei Motouchi. GH186 is a family of anomer-inverting enzymes from bacteria, members of which are specific for beta-1,2-glucans. Intriguingly, although some GH186 members work as classic glycoside hydrolases, others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack. Also notable, GH186 members appear to use an extended chain of water molecules to relay acceptor deprotonation by the general base residue, i.e. a Grotthuss mechanism. Check out the GH186 page to learn more about these interesting enzymes, and make sure to see the GH189, GH144, and GH162 pages from this same group.

2 May 2024: CBDs I to X... A major milestone! CBM families 1 to 10 are now complete! These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective CAZypedia pages: CBM1, CBM2, CBM3, CBM4, CBM5, CBM6, CBM7, CBM8, CBM9, and CBM10.

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