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Difference between revisions of "Template:News"

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'''6 January 2014:''' ''A new year, a new CBM page!'' The '''[[Carbohydrate Binding Module Family 6]]''' page was completed and given [[Curator Approved]] status today by [[Author]] and [[Responsible Curator|Curator]] '''[[User:Mirjam Czjzek|Mirjam Czjzek]]'''.  '''[[CBM6]]''' was originally defined based on the observation of xylan binding, however the diversity of substrate specificities in this family has now grown to include diverse beta-glucans, chitin, and even the marine polysaccharide agarose; remarkably, some '''[[CBM6]]''' members also contain two distinct binding sites.  The '''[[CBM6]]''' page is ''CAZypedia's'' second [[Carbohydrate Binding Module Families|Carbohydrate Binding Module Family]] page, and we [[CAZypedia:Assigned_pages#Carbohydrate_Binding_Module_Families|look forward]] to the further expansion of this section in the new year!
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'''19 July 2024:''' ''Chalk-up one more for the GTs!'' The '''[[Glycosyltransferase Family 47]]''' page joined the small group of [[Curator Approved]] [[Glycosyltransferase Families]] pages in ''CAZypedia'' today. This entry was [[author]]ed by Ph.D. students '''[[User:Daniel Tehrani|Daniel Tehrani]]''' and '''[[User:Charlie Corulli|Charlie Corulli]]''', and [[Responsible Curator|Curated]] by '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' with input from '''[https://ccrc.uga.edu/team/kelley-moremen/ Kelley Moremen]'''.  Widely represented in plants, '''[[GT47]]''' members are anomer-[[inverting]] [[glycosyltransferases]], which are involved in the biosynthesis of several cell wall matrix polysaccharides.  Representatives from mammals are involved in heparin biosynthesis.  Correspondingly, members of [[GH47]] have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides.  ''This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!''
 
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'''18 December 2013:''' ''A new mannanase page:'' Today, '''[[User:Rohan Williams|Rohan Williams]]''' and '''[[User:Spencer Williams|Spencer Williams]]''' completed the '''[[Glycoside Hydrolase Family 113]]''' page. '''[[GH113]]''' is currently a very small family (120 members) with only one characterized member, the ''Alicyclobacillus acidocaldarius'' beta(1-4)-mannanase.  The seminal crystal structure of this enzyme revealed '''[[GH113]]''' to be a member of [[Clan]] GH-A.  A recent publication from the '''[[User:Spencer Williams|Williams]]''' team and collaborators illuminated further details of the '''[[GH113]]''' and '''[[GH26]]''' transition states using designed inhibitor-enzyme complexes.  ''Read more about this emerging family [[Glycoside Hydrolase Family 113|here]]!''
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'''9 July 2024:''' ''Yet another new family of beta-1,2-glucan-active enzymes!'' Today, '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''' [[Curator Approved]] the '''[[Glycoside Hydrolase Family 186]]''' page by '''[[User:Sei Motouchi|Sei Motouchi]]'''. '''[[GH186]]''' is a family of anomer-[[inverting]] enzymes from bacteria, members of which are specific for beta-1,2-glucans.  Intriguingly, although some [[GH186]] members work as classic [[glycoside hydrolases]], others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack.  Also notable, [[GH186]] members appear to use an extended chain of water molecules to relay acceptor deprotonation by the [[general base]] residue, ''i.e.'' a [https://en.wikipedia.org/wiki/Grotthuss_mechanism Grotthuss mechanism]. ''Check out the '''[[GH186]]''' page to learn more about these interesting enzymes, and make sure to see the [[GH189]], [[GH144]], and [[GH162]] pages from this same group.''
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'''New for fall 2013:''' ''The CAZy database [http://dx.doi.org/10.1093/nar/gkt1178 now presents enzyme ligands!]'' See any family's [http://www.cazy.org/GH5_structure.html "Structure" page] for examples.
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'''2 May 2024:''' ''CBDs I to X... A major milestone!'' '''CBM families 1 to 10 are now complete!''' These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective ''CAZypedia'' pages: '''[[CBM1]], [[CBM2]], [[CBM3]], [[CBM4]], [[CBM5]], [[CBM6]], [[CBM7]], [[CBM8]], [[CBM9]], and [[CBM10]]'''.  
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'''6 October 2013:''' '''''[[GH66]]''' page upgraded to [[Curator Approved]] status:'' Today, [[Responsible Curator]] '''[[User:Zui Fujimoto|Zui Fujimoto]]''' formally approved the '''[[Glycoside Hydrolase Family 66]]''' page, [[Author]]ed by '''[[User:Ryuichiro Suzuki|Ryuichiro Suzuki]]''', as complete and ready for public viewing.  '''[[GH66]]''' is a very small family, currently containing ca. 60 members, of α(1-6)-glucan hydrolases (a.k.a. dextranases) and cyclo-isomalto-oligosaccharide glucanotransferases.  Through a series of elegant studies including biochemical and crystallographic analyses, '''[[User:Zui Fujimoto|Dr. Fujimoto]]''' and his collaborators have provided direct insight into catalysis by this unique family. ''Read more about the long history of these enzymes [[Glycoside Hydrolase Family 66|here]]!''
 
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'''30 September 2013:''' ''Our first PL page!:'' '''[[User:Wade Abbott|Wade Abbott]]''' finalized ''CAZypedia's'' first [[Polysaccharide Lyase Families|Polysaccharide Lyase Family]] page, '''[[PL2]]''', today.  As with our recent foray into [[Carbohydrate Binding Module Families|CBM families]] (see our May 22 news item) the extension of ''CAZypedia'' to include the [[Polysaccharide Lyase Families|PLs]] ushers in a new phase in our development, and we are very much looking forward to the evolution of this new group of pages, spearheaded by '''[[User:Wade Abbott|Wade Abbott]]''' and '''[[User:Michael Suits|Michael Suits]]'''.  ''If you are an expert on any of the [http://www.cazy.org/Polysaccharide-Lyases.html 22 PL families in the CAZy Database] and would like to contribute to ''CAZypedia'', please contact us [[Special:Contact|here]].
 
 
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Latest revision as of 09:56, 22 July 2024

19 July 2024: Chalk-up one more for the GTs! The Glycosyltransferase Family 47 page joined the small group of Curator Approved Glycosyltransferase Families pages in CAZypedia today. This entry was authored by Ph.D. students Daniel Tehrani and Charlie Corulli, and Curated by Breeanna Urbanowicz with input from Kelley Moremen. Widely represented in plants, GT47 members are anomer-inverting glycosyltransferases, which are involved in the biosynthesis of several cell wall matrix polysaccharides. Representatives from mammals are involved in heparin biosynthesis. Correspondingly, members of GH47 have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides. This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!

9 July 2024: Yet another new family of beta-1,2-glucan-active enzymes! Today, Masahiro Nakajima Curator Approved the Glycoside Hydrolase Family 186 page by Sei Motouchi. GH186 is a family of anomer-inverting enzymes from bacteria, members of which are specific for beta-1,2-glucans. Intriguingly, although some GH186 members work as classic glycoside hydrolases, others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack. Also notable, GH186 members appear to use an extended chain of water molecules to relay acceptor deprotonation by the general base residue, i.e. a Grotthuss mechanism. Check out the GH186 page to learn more about these interesting enzymes, and make sure to see the GH189, GH144, and GH162 pages from this same group.

2 May 2024: CBDs I to X... A major milestone! CBM families 1 to 10 are now complete! These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective CAZypedia pages: CBM1, CBM2, CBM3, CBM4, CBM5, CBM6, CBM7, CBM8, CBM9, and CBM10.

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