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Difference between revisions of "Polysaccharide Lyase Family 32"
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| + | * [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]] | ||
| + | * [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]] | ||
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| + | === PL32 is a deleted family === | ||
| + | The PL32 family was created following the functional characterization of the ORF “HMPREF1071_02769” from ''Bacteroides salyersiae ''CL02T12C01 (EIY62149.1), which showed endo-mannuronan lyase activity ([{{EClink}}4.2.2.3 EC 4.2.2.3]) <cite>Helbert2019</cite>. Shortly afterwards, the sequence was <u>'''reclassified'''</u> as [http://www.cazy.org/PL0.html PL_nc] on the basis of structural modelling revealing that the catalytic domain was restricted to the N-terminal domain <cite>Drula2022</cite>. The small number of sequences and the proximity to the [[PL14]] and [[PL36]] families do not allow the creation of a new PL family. | ||
| + | |||
| + | == References == | ||
| + | <biblio> | ||
| + | #Helbert2019 pmid=30850540 | ||
| + | |||
| + | #Drula2022 pmid=34850161 | ||
| + | |||
| + | </biblio> | ||
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[[Category:Polysaccharide Lyase Families|PL032]] | [[Category:Polysaccharide Lyase Families|PL032]] | ||
Latest revision as of 15:42, 1 October 2024
This page has been approved by the Responsible Curator as essentially complete. CAZypedia is a living document, so further improvement of this page is still possible. If you would like to suggest an addition or correction, please contact the page's Responsible Curator directly by e-mail.
This family has been deleted from the CAZy classification. A specific explanation may be found below.
PL32 is a deleted family
The PL32 family was created following the functional characterization of the ORF “HMPREF1071_02769” from Bacteroides salyersiae CL02T12C01 (EIY62149.1), which showed endo-mannuronan lyase activity (EC 4.2.2.3) [1]. Shortly afterwards, the sequence was reclassified as PL_nc on the basis of structural modelling revealing that the catalytic domain was restricted to the N-terminal domain [2]. The small number of sequences and the proximity to the PL14 and PL36 families do not allow the creation of a new PL family.
References
- Helbert W, Poulet L, Drouillard S, Mathieu S, Loiodice M, Couturier M, Lombard V, Terrapon N, Turchetto J, Vincentelli R, and Henrissat B. (2019). Discovery of novel carbohydrate-active enzymes through the rational exploration of the protein sequences space. Proc Natl Acad Sci U S A. 2019;116(13):6063-6068. DOI:10.1073/pnas.1815791116 |
- Drula E, Garron ML, Dogan S, Lombard V, Henrissat B, and Terrapon N. (2022). The carbohydrate-active enzyme database: functions and literature. Nucleic Acids Res. 2022;50(D1):D571-D577. DOI:10.1093/nar/gkab1045 |
| CAZy DB links | |
| https://www.cazy.org/PL32.html |