CAZypedia needs your help!
We have many unassigned pages in need of Authors and Responsible Curators. See a page that's out-of-date and just needs a touch-up? - You are also welcome to become a CAZypedian. Here's how.
Scientists at all career stages, including students, are welcome to contribute.
Learn more about CAZypedia's misson here and in this article.
 Totally new to the CAZy classification? Read this first.

Difference between revisions of "Template:News"

From CAZypedia
Jump to navigation Jump to search
 
(452 intermediate revisions by 3 users not shown)
Line 1: Line 1:
−
'''11 Jan 2012:''' ''New for the new year:'' '''CAZypedia''' is proud to report that our first new page of 2012, the '''[[Glycoside Hydrolase Family 99]]''' page, has been completed by '''[[User:Spencer Williams|Spencer Williams]]''' and given [[:Category:Curator approved|Curator Approved]] status today.  The page follows the recent publication of seminal structural and mechanistic analyses by a multi-investigator team including '''CAZypedia''' Curators '''[[User:Spencer Williams|Spencer Williams]]''' and '''[[User:Gideon Davies|Gideon Davies]]''', which suggests that endo-mannosidases of this family may use an unusual mechanism involving a 1,2-anhydro-β-
+
'''25 October 2024:''' ''Laminariawesome!'' Check out two new marine families of CBMs, '''[[CBM102]]''' and '''[[CBM103]]''', now on ''CAZypedia'' which have an ecological role in bacterial degradation of laminarin during phytoplankton blooms.  Some function as surface glycan binding proteins but others have roles in targeting their appended catalytic modules to substrate.  Both pages were [[author]]ed by '''[[User:Marie-Katherin Zuehlke|Marie-Katherin Zühlke]]'''. ''Read up on these environmentally important CBMs on their respective [[CBM102]] and [[CBM103]] pages!''  
−
mannopyranose  ("sugar epoxide") intermediate to effect the release of Glc<sub>1–3</sub>-1,3-α-Man oligosaccharides during N-glycan trimming. '''[[GH99]]''' is a small, but nonetheless important family, whose members come from both higher eukaryotes, which employ these enzymes in protein-folding quality-control, and bacteria, which may use their homologues for carbohydrate scavenging in, e.g., the human gut.
 
 
----
 
----
−
'''18 July 2011:''' ''Our second GH-I chitosanase page:'' '''[[User:Ryszard Brzezinski|Ryszard Brzezinski]]''' has recently completed and [[:Category:Curator approved|Curator Approved]] his second page on chitosanases, enzymes which act specifically on the de-acetylated form of chitin (the polysaccharide chitin is a widespread in Nature as a main component of insect bodies and crustacean shells). '''[[Glycoside Hydrolase Family 80]]''', a member of [[Clan]] GH-I together with [[GH24]] and [[GH46]], is a remarkably small family, which has thus far received only limited experimental attention.  We therefore look forward to the expansion of this page with structural and mechanistic data in the future. ''Coincidentally, the '''[[GH80]]''' page is our '''80th''' [[:Category:Curator approved|Curator Approved]] [[Glycoside Hydrolase Families|Glycoside Hydrolase Family]] page in CAZypedia!''
+
'''19 July 2024:''' ''Chalk-up one more for the GTs!'' The '''[[Glycosyltransferase Family 47]]''' page joined the small group of [[Curator Approved]] [[Glycosyltransferase Families]] pages in ''CAZypedia'' today. This entry was [[author]]ed by Ph.D. students '''[[User:Daniel Tehrani|Daniel Tehrani]]''' and '''[[User:Charlie Corulli|Charlie Corulli]]''', and [[Responsible Curator|Curated]] by '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' with input from '''[https://ccrc.uga.edu/team/kelley-moremen/ Kelley Moremen]'''.  Widely represented in plants, '''[[GT47]]''' members are anomer-[[inverting]] [[glycosyltransferases]], which are involved in the biosynthesis of several cell wall matrix polysaccharides.  Representatives from mammals are involved in heparin biosynthesis.  Correspondingly, members of [[GH47]] have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides.  ''This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!''
 
----
 
----
−
'''20 June 2011:''' ''More phosphorylases:'' On May 29, [[Author]] and [[Responsible Curator]] '''[[User:Hiroyuki Nakai|Hiroyuki Nakai]]''' completed the '''[[Glycoside Hydrolase Family 65]]''' page. '''[[GH65]]''' is comprised of alpha-glycoside phosphorylases and alpha,alpha-trehalose hydrolases. Due to the readily reversible nature of phosphorolysis, '''[[GH65]]''' enzymes have been harnessed for glycoside synthesis, including recent work by '''[[User:Hiroyuki Nakai|Dr. Nakai]]'''. The completion of the '''[[GH65]]''' complements previously completed pages on the beta-glycoside phosphorylases of [[GH94]] and [[GH112]] in ''CAZypedia''.
+
'''9 July 2024:''' ''Yet another new family of beta-1,2-glucan-active enzymes!'' Today, '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''' [[Curator Approved]] the '''[[Glycoside Hydrolase Family 186]]''' page by '''[[User:Sei Motouchi|Sei Motouchi]]'''. '''[[GH186]]''' is a family of anomer-[[inverting]] enzymes from bacteria, members of which are specific for beta-1,2-glucans.  Intriguingly, although some [[GH186]] members work as classic [[glycoside hydrolases]], others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack.  Also notable, [[GH186]] members appear to use an extended chain of water molecules to relay acceptor deprotonation by the [[general base]] residue, ''i.e.'' a [https://en.wikipedia.org/wiki/Grotthuss_mechanism Grotthuss mechanism]. ''Check out the '''[[GH186]]''' page to learn more about these interesting enzymes, and make sure to see the [[GH189]], [[GH144]], and [[GH162]] pages from this same group.''
 +
 
 
----
 
----
−
'''12 May 2011:''' ''A new page on a new-ish family:'' [[Author]] and [[Responsible Curator]] '''[[User:Satoshi Kaneko|Satoshi Kaneko]]'''  completed the '''[[Glycoside Hydrolase Family 115]]''' page today.  '''[[GH115]]''' contains microbial alpha-glucuronidases, which are involved the cleavage of D-glucuronic acid and 4-O-methyl-D-glucuronic acid sidechains from xylans.  Remarkably, '''[[GH115]]''' enzymes can release these monosaccharides from intact polymer chains, which is rather rare for exo-acting enzymes, and contrasts them with glucuronidases from '''[[GH67]]'''.  Although this regiospecific activity has been known since the last millenium, it was only in 2009 that these particular enzymes nucleated their own GH family.
+
'''2 May 2024:''' ''CBDs I to X... A major milestone!'' '''CBM families 1 to 10 are now complete!''' These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective ''CAZypedia'' pages: '''[[CBM1]], [[CBM2]], [[CBM3]], [[CBM4]], [[CBM5]], [[CBM6]], [[CBM7]], [[CBM8]], [[CBM9]], and [[CBM10]]'''.  
 
----
 
----

Latest revision as of 05:59, 31 October 2024

25 October 2024: Laminariawesome! Check out two new marine families of CBMs, CBM102 and CBM103, now on CAZypedia which have an ecological role in bacterial degradation of laminarin during phytoplankton blooms. Some function as surface glycan binding proteins but others have roles in targeting their appended catalytic modules to substrate. Both pages were authored by Marie-Katherin Zühlke. Read up on these environmentally important CBMs on their respective CBM102 and CBM103 pages!

19 July 2024: Chalk-up one more for the GTs! The Glycosyltransferase Family 47 page joined the small group of Curator Approved Glycosyltransferase Families pages in CAZypedia today. This entry was authored by Ph.D. students Daniel Tehrani and Charlie Corulli, and Curated by Breeanna Urbanowicz with input from Kelley Moremen. Widely represented in plants, GT47 members are anomer-inverting glycosyltransferases, which are involved in the biosynthesis of several cell wall matrix polysaccharides. Representatives from mammals are involved in heparin biosynthesis. Correspondingly, members of GH47 have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides. This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!

9 July 2024: Yet another new family of beta-1,2-glucan-active enzymes! Today, Masahiro Nakajima Curator Approved the Glycoside Hydrolase Family 186 page by Sei Motouchi. GH186 is a family of anomer-inverting enzymes from bacteria, members of which are specific for beta-1,2-glucans. Intriguingly, although some GH186 members work as classic glycoside hydrolases, others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack. Also notable, GH186 members appear to use an extended chain of water molecules to relay acceptor deprotonation by the general base residue, i.e. a Grotthuss mechanism. Check out the GH186 page to learn more about these interesting enzymes, and make sure to see the GH189, GH144, and GH162 pages from this same group.

2 May 2024: CBDs I to X... A major milestone! CBM families 1 to 10 are now complete! These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective CAZypedia pages: CBM1, CBM2, CBM3, CBM4, CBM5, CBM6, CBM7, CBM8, CBM9, and CBM10.

Retrieved from "http://www.cazypedia.org/index.php?title=Template:News&oldid=18533"