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Difference between revisions of "Template:News"

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'''16 Jan 2013:''' ''Class I mannosidases &times; Williams<sup>2</sup> = 90<sup>th</sup> CAZypedia GH page.'' '''[[User:Rohan Williams|Rohan Williams]]''' and '''[[User:Spencer Williams|Spencer Williams]]''' completed the '''[[Glycoside Hydrolase Family 47]]''' page today to give CAZypedia its 90<sup>th</sup> [[:Category:Curator approved|Curator Approved]] GH page.  '''[[GH47]]''' is particularly important because it contains alpha-1,2 mannosidases that are responsible for N-glycan processing in eukaryotes.  Delineated by subfamily membership, these eukaryotic mannosidases function either in glycoprotein maturation or endoplasmic reticulum-associated degradation (ERAD).  In contrast, very few bacterial '''[[GH47]]''' members are known, and their function(s) has not been widely studied.  From a mechanistic perspective, '''[[GH47]]''' members are intriguing because the catalytic residues have not been unambiguously identified, despite high-resolution structure-function studies of these [[inverting]] enzymes.  ''Check out the [[GH47]] to learn more!''
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'''25 October 2024:''' ''Laminariawesome!'' Check out two new marine families of CBMs, '''[[CBM102]]''' and '''[[CBM103]]''', now on ''CAZypedia'' which have an ecological role in bacterial degradation of laminarin during phytoplankton blooms.  Some function as surface glycan binding proteins but others have roles in targeting their appended catalytic modules to substrate.  Both pages were [[author]]ed by '''[[User:Marie-Katherin Zuehlke|Marie-Katherin Zühlke]]'''. ''Read up on these environmentally important CBMs on their respective [[CBM102]] and [[CBM103]] pages!''  
 
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'''14 Jan 2013:''' ''CAZypedia makes a contribution to MediaWiki community.'' We are proud to announce that [http://www.mediawiki.org/wiki/Extension:BiblioPlus BiblioPlus], an extension that provides automatic reference formatting to CAZypedia, has been officially accepted by the [http://www.mediawiki.org/wiki/Extension:BiblioPlus MediaWiki Extensions repository]. [http://www.mediawiki.org/wiki/Extension:BiblioPlus BiblioPlus] was coded by '''[[User:Karen Eddy|Karen Eddy]]''', a UBC computer science student working with '''[[User:Harry Brumer|Harry Brumer]]''', to resolve formatting issues with non-Western characters in PubMed data.  [http://www.mediawiki.org/wiki/Extension:BiblioPlus BiblioPlus] is now available for anyone to use with any MediaWiki-based site to facilitate referencing journals and books. ''Thanks Karen, for all the hard work!''
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'''19 July 2024:''' ''Chalk-up one more for the GTs!'' The '''[[Glycosyltransferase Family 47]]''' page joined the small group of [[Curator Approved]] [[Glycosyltransferase Families]] pages in ''CAZypedia'' today. This entry was [[author]]ed by Ph.D. students '''[[User:Daniel Tehrani|Daniel Tehrani]]''' and '''[[User:Charlie Corulli|Charlie Corulli]]''', and [[Responsible Curator|Curated]] by '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' with input from '''[https://ccrc.uga.edu/team/kelley-moremen/ Kelley Moremen]'''.  Widely represented in plants, '''[[GT47]]''' members are anomer-[[inverting]] [[glycosyltransferases]], which are involved in the biosynthesis of several cell wall matrix polysaccharides.  Representatives from mammals are involved in heparin biosynthesis.  Correspondingly, members of [[GH47]] have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides. ''This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!''
 
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'''02 Dec 2012:''' ''Spencer does it again, twice.'' '''[[User:Spencer Williams|Spencer Williams]]''' has upgraded another two [[lexicon]] pages to [[:Category:Curator approved|Curator Approved]] status today.  Have no idea what '''[[Oxazolinium ion]]s''' and '''[[Oxocarbenium ion]]s''' are, or why they're important in [[glycosidase]]s?  ''Check out these new pages!''
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'''9 July 2024:''' ''Yet another new family of beta-1,2-glucan-active enzymes!'' Today, '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''' [[Curator Approved]] the '''[[Glycoside Hydrolase Family 186]]''' page by '''[[User:Sei Motouchi|Sei Motouchi]]'''. '''[[GH186]]''' is a family of anomer-[[inverting]] enzymes from bacteria, members of which are specific for beta-1,2-glucans.  Intriguingly, although some [[GH186]] members work as classic [[glycoside hydrolases]], others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack.  Also notable, [[GH186]] members appear to use an extended chain of water molecules to relay acceptor deprotonation by the [[general base]] residue, ''i.e.'' a [https://en.wikipedia.org/wiki/Grotthuss_mechanism Grotthuss mechanism]. ''Check out the '''[[GH186]]''' page to learn more about these interesting enzymes, and make sure to see the [[GH189]], [[GH144]], and [[GH162]] pages from this same group.''
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'''20 Nov 2012:''' ''A growing lexicon, II:'' '''[[User:Spencer Williams|Spencer Williams]]''' has upgraded the '''[[Glycosyltransferases]]''' [[lexicon]] page to [[:Category:Curator approved|Curator Approved]] status today. This class of enzymes catalyzes the biosynthesis of the tremendous natural diversity of glycosides from activated sugar donor substrates and, as such, this page forms an essential part of ''CAZypedia's'' [[lexicon]] of terms and concepts.  ''Thanks [[User:Spencer Williams|Spencer]], for continuing to develop this resource!''
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'''2 May 2024:''' ''CBDs I to X... A major milestone!'' '''CBM families 1 to 10 are now complete!''' These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective ''CAZypedia'' pages: '''[[CBM1]], [[CBM2]], [[CBM3]], [[CBM4]], [[CBM5]], [[CBM6]], [[CBM7]], [[CBM8]], [[CBM9]], and [[CBM10]]'''.  
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'''16 Nov 2012:''' ''N-glycan deconstruction:'' There's been a flurry of activity on ''CAZypedia'' this past week; today, '''[[User:Al Boraston|Al Boraston]]''' completed the '''[[Glycoside Hydrolase Family 125]]''' page.  '''[[GH125]]''' was established last year based on a collaborative study between the '''[[User:Al Boraston|Boraston]]''' and '''[[User:David Vocadlo|Vocadlo]]''' groups, which demonstrated that certain members from human bacterial pathogens can cleave alpha(1-6) mannosyl linkages typical of human N-glycans.  Notably, '''[[GH125]]''' members are also found in human gut symbiotic bacteria and pathogenic fungi, which underscores their potential biological importance in N-glycan deconstruction.  ''Check out the '''[[GH125]]''' page to read more about this new family, including a link to '''[[User:David Vocadlo|David]]''' and '''[[User:Al Boraston|Al's]]''' seminal publication.''
 
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'''15 Nov 2012:''' ''A growing lexicon:'' [[News|Back in January of 2010]], '''[[User:Wim Nerinckx|Wim Nerinckx]]''' compiled a monumental table on the [[Syn/anti lateral protonation|orientation of the catalytic acid/base residue]] in over 70 GH families.  '''[[User:Wim Nerinckx|Wim]]''' has now elaborated this page with an essential introduction to the important concept of '''[[Syn/anti lateral protonation]]''' in glycosidase catalysis, which was outlined in a seminal paper by Tom Heightman and Andrea Vasella in 1999.  Now updated to [[:Category:Curator approved|Curator Approved]] from [[:Category:Under construction|Under Construction]] status, this page forms a key part of ''CAZypedia's'' [[lexicon]] of terms and concepts.
 
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'''12 Nov 2012:''' ''<u>Three</u> new GH families:'' Thanks to our colleagues in Japan, three pages on recently established glycoside hydrolase families have been completed and given [[:Category:Curator approved|Curator Approved]] status in ''CAZypedia'' today.  The '''[[GH121]]''' and '''[[GH127]]''' family pages by '''[[User:Kiyotaka Fujita|Kiyotaka Fujita]]''' describe ''Bifidobacterium longum'' enzymes involved in plant hydroxyproline-rich glycoprotein (HRGP) deconstruction.  The '''[[GH129]]''' page by '''[[User:Hisashi Ashida|Hisashi Ashida]]''' describes another family of Bifidobacterial enzymes, which in this case, appear to be involved in mucin glycoprotein degradation.  Special thanks go to [[Responsible Curator]] '''[[User:Shinya Fushinobu|Shinya Fushinobu]]''' for organizing the production of these important new pages!
 
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'''25 Oct 2012:''' ''A new GH family is born:'' '''[[User:Jean-Guy Berrin|Jean-Guy Berrin]]''' and his team at INRA in Marseille have recently unveiled a new glycoside hydrolase family, '''[[Glycoside Hydrolase Family 131]]''', through elegant biochemical studies on a bi-modular &beta;-glucanase from the fungus ''Podospora anserina''.  We are pleased to report that '''[[User:Jean-Guy Berrin|Jean-Guy]]''' has completed and given [[:Category:Curator approved|Curator Approved]] status to this fledgling ''CAZypedia'' page today, on which you can [[Glycoside Hydrolase Family 131|learn more about the INRA team's seminal work]].
 
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'''05 Sep 2012:''' ''Transglucosylases:'' The '''[[Glycoside Hydrolase Family 70]]''' page by '''[[User:Magali Remaud-Simeon|Magali Remaud-Simeon]]''' has been copy-edited by [[Responsible Curator]] '''[[User:Stefan Janecek|Stefan Janecek]]''' and given [[:Category:Curator approved|Curator Approved]] status today.  '''[[GH70]]''' comprises a family of enzymes with the notable ability to build high molecular weight &alpha;-glucan polysaccharides from sucrose as a glucosyl donor substrate.  Depending the particular enzyme, &alpha;-1,2-; &alpha;-1,3-; &alpha;-1,4-; and/or &alpha;-1,6-linked glucans can be produced, which have applications in food, pharmaceutical, and fine chemical industries.  In addition, biofilms of &alpha;-1,3-glucans produced by the '''[[GH70]]''' enzymes of oral bacteria are also implicated in the formation of dental caries (cavities). Learn more about this interesting family of CAZymes [[Glycoside Hydrolase Family 70|here]]!
 
 
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Latest revision as of 05:59, 31 October 2024

25 October 2024: Laminariawesome! Check out two new marine families of CBMs, CBM102 and CBM103, now on CAZypedia which have an ecological role in bacterial degradation of laminarin during phytoplankton blooms. Some function as surface glycan binding proteins but others have roles in targeting their appended catalytic modules to substrate. Both pages were authored by Marie-Katherin Zühlke. Read up on these environmentally important CBMs on their respective CBM102 and CBM103 pages!

19 July 2024: Chalk-up one more for the GTs! The Glycosyltransferase Family 47 page joined the small group of Curator Approved Glycosyltransferase Families pages in CAZypedia today. This entry was authored by Ph.D. students Daniel Tehrani and Charlie Corulli, and Curated by Breeanna Urbanowicz with input from Kelley Moremen. Widely represented in plants, GT47 members are anomer-inverting glycosyltransferases, which are involved in the biosynthesis of several cell wall matrix polysaccharides. Representatives from mammals are involved in heparin biosynthesis. Correspondingly, members of GH47 have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides. This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!

9 July 2024: Yet another new family of beta-1,2-glucan-active enzymes! Today, Masahiro Nakajima Curator Approved the Glycoside Hydrolase Family 186 page by Sei Motouchi. GH186 is a family of anomer-inverting enzymes from bacteria, members of which are specific for beta-1,2-glucans. Intriguingly, although some GH186 members work as classic glycoside hydrolases, others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack. Also notable, GH186 members appear to use an extended chain of water molecules to relay acceptor deprotonation by the general base residue, i.e. a Grotthuss mechanism. Check out the GH186 page to learn more about these interesting enzymes, and make sure to see the GH189, GH144, and GH162 pages from this same group.

2 May 2024: CBDs I to X... A major milestone! CBM families 1 to 10 are now complete! These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective CAZypedia pages: CBM1, CBM2, CBM3, CBM4, CBM5, CBM6, CBM7, CBM8, CBM9, and CBM10.

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