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Difference between revisions of "Glycoside Hydrolase Family 101"
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(New page: <div style="float:right"> {| {{Prettytable}} |- |{{Hl2}} colspan="2" align="center" |'''Glycoside Hydrolase Family GHnn''' |- |'''Clan''' |GH-x |- |'''Mechanism''' |retaining/inve...) |
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{| {{Prettytable}} | {| {{Prettytable}} | ||
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| − | |{{Hl2}} colspan="2" align="center" |'''Glycoside Hydrolase Family | + | |{{Hl2}} colspan="2" align="center" |'''Glycoside Hydrolase Family GH101''' |
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|'''Clan''' | |'''Clan''' | ||
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|'''Mechanism''' | |'''Mechanism''' | ||
| − | |retaining | + | |retaining |
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|'''Active site residues''' | |'''Active site residues''' | ||
| − | | | + | |known |
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|{{Hl2}} colspan="2" align="center" |'''CAZy DB link''' | |{{Hl2}} colspan="2" align="center" |'''CAZy DB link''' | ||
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| − | | colspan="2" |http://www.cazy.org/fam/ | + | | colspan="2" |http://www.cazy.org/fam/GH101.html |
|} | |} | ||
</div> | </div> | ||
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== Substrate specificities == | == Substrate specificities == | ||
| − | + | Gal-beta-1,3-GalNAc-alpha-R ''O''-linked glycans on proteins | |
== Kinetics and Mechanism == | == Kinetics and Mechanism == | ||
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== Catalytic Residues == | == Catalytic Residues == | ||
| − | + | Nucleophile SpGH101 D764 | |
| + | Acid/base catalyst SpGH101 E796 | ||
Revision as of 13:49, 18 June 2009
| Glycoside Hydrolase Family GH101 | |
| Clan | GH-x |
| Mechanism | retaining |
| Active site residues | known |
| CAZy DB link | |
| http://www.cazy.org/fam/GH101.html | |
Substrate specificities
Gal-beta-1,3-GalNAc-alpha-R O-linked glycans on proteins
Kinetics and Mechanism
Catalytic Residues
Nucleophile SpGH101 D764 Acid/base catalyst SpGH101 E796
Three-dimensional structures
Family Firsts
- First sterochemistry determination
- Cite some reference here, with a short explanation [1].
- First catalytic nucleophile identification
- First general acid/base residue identification
- First 3-D structure
References
- Comfort DA, Bobrov KS, Ivanen DR, Shabalin KA, Harris JM, Kulminskaya AA, Brumer H, and Kelly RM. (2007). Biochemical analysis of Thermotoga maritima GH36 alpha-galactosidase (TmGalA) confirms the mechanistic commonality of clan GH-D glycoside hydrolases. Biochemistry. 2007;46(11):3319-30. DOI:10.1021/bi061521n |
[[Category:Glycoside Hydrolase Families]]