CAZypedia needs your help!
We have many unassigned pages in need of Authors and Responsible Curators. See a page that's out-of-date and just needs a touch-up? - You are also welcome to become a CAZypedian. Here's how.
Scientists at all career stages, including students, are welcome to contribute.
Learn more about CAZypedia's misson here and in this article.
Totally new to the CAZy classification? Read this first.
Difference between revisions of "Glycoside Hydrolase Family 63"
| Line 29: | Line 29: | ||
== Substrate specificities == | == Substrate specificities == | ||
| − | Glycoside hydrolases of this family are exo-acting inverting enzymes. The most commonly characterized activity of the eukaryotic enzymes is processing α glucosidase I (EC 3.2.1.106), which specifically hydrolyzes the terminal α-1,2-glucosidic linkage in the ''N''-linked oligosacharide precursor, Glc<sub>3</sub>Man<sub>9</sub>GlcNAc<sub>2</sub>. The enzymatic properties of Cwh41p, a processing α glucosidase I from ''Saccharomyces cerevisiae'', has been most intensively studied. | + | Glycoside hydrolases of this family are exo-acting inverting enzymes. The most commonly characterized activity of the eukaryotic enzymes is processing α-glucosidase I (EC 3.2.1.106), which specifically hydrolyzes the terminal α-1,2-glucosidic linkage in the ''N''-linked oligosacharide precursor, Glc<sub>3</sub>Man<sub>9</sub>GlcNAc<sub>2</sub>. The enzymatic properties of Cwh41p, a processing α glucosidase I from ''Saccharomyces cerevisiae'', has been most intensively studied. |
Revision as of 02:13, 20 April 2011
This page is currently under construction. This means that the Responsible Curator has deemed that the page's content is not quite up to CAZypedia's standards for full public consumption. All information should be considered to be under revision and may be subject to major changes.
- Author: ^^^Takashi Tonozuka^^^
- Responsible Curator: ^^^Takashi Tonozuka^^^
| Glycoside Hydrolase Family GH63 | |
| Clan | GH-G |
| Mechanism | inverting |
| Active site residues | not known |
| CAZy DB link | |
| https://www.cazy.org/GH63.html | |
Substrate specificities
Glycoside hydrolases of this family are exo-acting inverting enzymes. The most commonly characterized activity of the eukaryotic enzymes is processing α-glucosidase I (EC 3.2.1.106), which specifically hydrolyzes the terminal α-1,2-glucosidic linkage in the N-linked oligosacharide precursor, Glc3Man9GlcNAc2. The enzymatic properties of Cwh41p, a processing α glucosidase I from Saccharomyces cerevisiae, has been most intensively studied.
This is an example of how to make references to a journal article [1]. (See the References section below). Multiple references can go in the same place like this [1, 2]. You can even cite books using just the ISBN [3]. References that are not in PubMed can be typed in by hand [4].
Kinetics and Mechanism
Content is to be added here.
Catalytic Residues
Content is to be added here.
Three-dimensional structures
Content is to be added here.
Family Firsts
- First stereochemistry determination
- Cite some reference here, with a short (1-2 sentence) explanation [1].
- First catalytic nucleophile identification
- Cite some reference here, with a short (1-2 sentence) explanation [4].
- First general acid/base residue identification
- Cite some reference here, with a short (1-2 sentence) explanation [2].
- First 3-D structure
- Cite some reference here, with a short (1-2 sentence) explanation [3].
References
Error fetching PMID 9312086:
- Error fetching PMID 17323919:
- Error fetching PMID 9312086:
-
Sinnott, M.L. (1990) Catalytic mechanisms of enzymic glycosyl transfer. Chem. Rev. 90, 1171-1202. DOI: 10.1021/cr00105a006