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Difference between revisions of "Template:CBMFamilyPage"
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Include here Type A, B, or C and properties | Include here Type A, B, or C and properties | ||
| − | === | + | ===Features of ligand binding=== |
| − | + | Describe CBM binding pocket location (Side or apex) important residues for binding (W, Y, F, subsites), interact with reducing end, non-reducing end or within polysaccharide chains. Include examples pdb codes. Metal ion dependent. Etc. | |
== Functionalities == | == Functionalities == | ||
Revision as of 01:32, 7 May 2013
{{UnderConstruction}}
- Author: ^^^Alicia Lammerts van Bueren^^^
- Responsible Curator: ^^^Alicia Lammerts van Bueren^^^
Page content has yet to be added. In the meantime, please see these references for an essential introduction to the CAZy classification system: [1, 2]. CBMs, in particular, have been extensively reviewed [3, 4, 5, 6].
Ligand specificities
Mention here all major natural ligand specificities that are found within a given family (also plant or mammalian origin). Certain linkages and promiscuity would also be mentioned here if biologically relevant.
Structural Features
Fold
Structural fold (beta trefoil, beta sandwich, etc.)
Type
Include here Type A, B, or C and properties
Features of ligand binding
Describe CBM binding pocket location (Side or apex) important residues for binding (W, Y, F, subsites), interact with reducing end, non-reducing end or within polysaccharide chains. Include examples pdb codes. Metal ion dependent. Etc.
Functionalities
Functional role of CBM
Describe common functional roles such as targeting, disruptive, anchoring, proximity/position on substrate.
Most Common Associated Modules
1. Glycoside Hydrolase Activity
2. Additional Associated Modules (other CBM, FNIII, cohesin, dockerins, expansins, etc.)
Novel Applications
Include here if CBM has been used to modify another enzyme, or if a CBM was used to label plant/mammalian tissues? Etc.
Family Firsts
First Identified
insert text here
First Structural Characterization
insert text here
References
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Davies, G.J. and Sinnott, M.L. (2008) Sorting the diverse: the sequence-based classifications of carbohydrate-active enzymes. Biochem. J. (BJ Classic Paper, online only). DOI: 10.1042/BJ20080382
- Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, and Henrissat B. (2009). The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics. Nucleic Acids Res. 2009;37(Database issue):D233-8. DOI:10.1093/nar/gkn663 |
- Boraston AB, Bolam DN, Gilbert HJ, and Davies GJ. (2004). Carbohydrate-binding modules: fine-tuning polysaccharide recognition. Biochem J. 2004;382(Pt 3):769-81. DOI:10.1042/BJ20040892 |
- Hashimoto H (2006). Recent structural studies of carbohydrate-binding modules. Cell Mol Life Sci. 2006;63(24):2954-67. DOI:10.1007/s00018-006-6195-3 |
- Shoseyov O, Shani Z, and Levy I. (2006). Carbohydrate binding modules: biochemical properties and novel applications. Microbiol Mol Biol Rev. 2006;70(2):283-95. DOI:10.1128/MMBR.00028-05 |
- Guillén D, Sánchez S, and Rodríguez-Sanoja R. (2010). Carbohydrate-binding domains: multiplicity of biological roles. Appl Microbiol Biotechnol. 2010;85(5):1241-9. DOI:10.1007/s00253-009-2331-y |
[[Category:Carbohydrate Binding Module Families|CBMnnn]]