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Difference between revisions of "Template:CBMFamilyPage"
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== Structural Features == | == Structural Features == | ||
| − | ''Content should include a description of:'' | + | ''Content in this section should include, in paragraph form, a description of:'' |
* '''Fold:''' Structural fold (beta trefoil, beta sandwich, etc.) | * '''Fold:''' Structural fold (beta trefoil, beta sandwich, etc.) | ||
* '''Type:''' Include here Type A, B, or C and properties | * '''Type:''' Include here Type A, B, or C and properties | ||
| Line 21: | Line 21: | ||
== Functionalities == | == Functionalities == | ||
| − | + | ''Content in this section should include, in paragraph form, a description of:'' | |
| − | Describe common functional roles such as targeting, disruptive, anchoring, proximity/position on substrate. | + | * '''Functional role of CBM:''' Describe common functional roles such as targeting, disruptive, anchoring, proximity/position on substrate. |
| − | + | * '''Most Common Associated Modules:''' 1. Glycoside Hydrolase Activity; 2. Additional Associated Modules (other CBM, FNIII, cohesin, dockerins, expansins, etc.) | |
| − | 1. Glycoside Hydrolase Activity | + | * '''Novel Applications:''' Include here if CBM has been used to modify another enzyme, or if a CBM was used to label plant/mammalian tissues? Etc. |
| − | |||
| − | 2. Additional Associated Modules (other CBM, FNIII, cohesin, dockerins, expansins, etc.) | ||
| − | |||
| − | Include here if CBM has been used to modify another enzyme, or if a CBM was used to label plant/mammalian tissues? Etc. | ||
== Family Firsts == | == Family Firsts == | ||
| − | + | ;First Identified | |
| − | + | :Insert archetype here, possibly including ''very brief'' synopsis. | |
| − | + | ;First Structural Characterization | |
| − | + | :Insert archetype here, possibly including ''very brief'' synopsis. | |
== References == | == References == | ||
Revision as of 10:03, 7 May 2013
{{UnderConstruction}}
- Author: ^^^Alicia Lammerts van Bueren^^^
- Responsible Curator: ^^^Alicia Lammerts van Bueren^^^
Page content has yet to be added. In the meantime, please see these references for an essential introduction to the CAZy classification system: [1, 2]. CBMs, in particular, have been extensively reviewed [3, 4, 5, 6].
Ligand specificities
Mention here all major natural ligand specificities that are found within a given family (also plant or mammalian origin). Certain linkages and promiscuity would also be mentioned here if biologically relevant.
Structural Features
Content in this section should include, in paragraph form, a description of:
- Fold: Structural fold (beta trefoil, beta sandwich, etc.)
- Type: Include here Type A, B, or C and properties
- Features of ligand binding: Describe CBM binding pocket location (Side or apex) important residues for binding (W, Y, F, subsites), interact with reducing end, non-reducing end, planar surface or within polysaccharide chains. Include examples pdb codes. Metal ion dependent. Etc.
Functionalities
Content in this section should include, in paragraph form, a description of:
- Functional role of CBM: Describe common functional roles such as targeting, disruptive, anchoring, proximity/position on substrate.
- Most Common Associated Modules: 1. Glycoside Hydrolase Activity; 2. Additional Associated Modules (other CBM, FNIII, cohesin, dockerins, expansins, etc.)
- Novel Applications: Include here if CBM has been used to modify another enzyme, or if a CBM was used to label plant/mammalian tissues? Etc.
Family Firsts
- First Identified
- Insert archetype here, possibly including very brief synopsis.
- First Structural Characterization
- Insert archetype here, possibly including very brief synopsis.
References
-
Davies, G.J. and Sinnott, M.L. (2008) Sorting the diverse: the sequence-based classifications of carbohydrate-active enzymes. Biochem. J. (BJ Classic Paper, online only). DOI: 10.1042/BJ20080382
- Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, and Henrissat B. (2009). The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics. Nucleic Acids Res. 2009;37(Database issue):D233-8. DOI:10.1093/nar/gkn663 |
- Boraston AB, Bolam DN, Gilbert HJ, and Davies GJ. (2004). Carbohydrate-binding modules: fine-tuning polysaccharide recognition. Biochem J. 2004;382(Pt 3):769-81. DOI:10.1042/BJ20040892 |
- Hashimoto H (2006). Recent structural studies of carbohydrate-binding modules. Cell Mol Life Sci. 2006;63(24):2954-67. DOI:10.1007/s00018-006-6195-3 |
- Shoseyov O, Shani Z, and Levy I. (2006). Carbohydrate binding modules: biochemical properties and novel applications. Microbiol Mol Biol Rev. 2006;70(2):283-95. DOI:10.1128/MMBR.00028-05 |
- Guillén D, Sánchez S, and Rodríguez-Sanoja R. (2010). Carbohydrate-binding domains: multiplicity of biological roles. Appl Microbiol Biotechnol. 2010;85(5):1241-9. DOI:10.1007/s00253-009-2331-y |
[[Category:Carbohydrate Binding Module Families|CBMnnn]]