CAZypedia needs your help!
We have many unassigned pages in need of Authors and Responsible Curators. See a page that's out-of-date and just needs a touch-up? - You are also welcome to become a CAZypedian. Here's how.
Scientists at all career stages, including students, are welcome to contribute.
Learn more about CAZypedia's misson here and in this article.
Totally new to the CAZy classification? Read this first.
Difference between revisions of "Polysaccharide Lyase Family 7"
| Line 28: | Line 28: | ||
== Substrate specificities == | == Substrate specificities == | ||
| − | The polysaccharide lyase family 7 (PL7) contains 5 subfamilies <cite>Lombard2010</cite>. All characterized members were | + | The polysaccharide lyase family 7 (PL7) contains 5 subfamilies <cite>Lombard2010</cite>. All characterized members were alginate lyases specific for the anionic, gel forming polysaccharide from brown seaweed such as kelps or from certain types of bacteria. Alginate consists of beta-D-mannuronate and alpha-L-guluronate, which occur in homogenous or heterogenous blocks. Hence, PL7 can be mannuronate, guluronate or mixed link lyases. PL7 enzymes are often found in marine bacteria such as the seaweed associated Flavobacterium Zobellia galactanivorans <cite>Thomas2013</cite> or in coastal, planktonic gammaproteobacteria such as Vibrio spp. |
| − | |||
== Catalytic Residues == | == Catalytic Residues == | ||
| Line 40: | Line 39: | ||
<biblio> | <biblio> | ||
#Lombard2010 pmid=20925655 | #Lombard2010 pmid=20925655 | ||
| + | #Thomas2013 pmid=23782694 | ||
</biblio> | </biblio> | ||
Revision as of 06:10, 17 February 2015
This page is currently under construction. This means that the Responsible Curator has deemed that the page's content is not quite up to CAZypedia's standards for full public consumption. All information should be considered to be under revision and may be subject to major changes.
- Author: ^^^Jan-Hendrik Hehemann^^^
- Responsible Curator: ^^^Wade Abbott^^^
| Polysaccharide Lyase Family PL7 | |
| 3D Structure | β jelly roll |
| Mechanism | β-elimination |
| Active site residues | known |
| CAZy DB link | |
| https://www.cazy.org/PL7.html | |
Substrate specificities
The polysaccharide lyase family 7 (PL7) contains 5 subfamilies [1]. All characterized members were alginate lyases specific for the anionic, gel forming polysaccharide from brown seaweed such as kelps or from certain types of bacteria. Alginate consists of beta-D-mannuronate and alpha-L-guluronate, which occur in homogenous or heterogenous blocks. Hence, PL7 can be mannuronate, guluronate or mixed link lyases. PL7 enzymes are often found in marine bacteria such as the seaweed associated Flavobacterium Zobellia galactanivorans [2] or in coastal, planktonic gammaproteobacteria such as Vibrio spp.
Catalytic Residues
Three-dimensional structures
Family Firsts
References
- Lombard V, Bernard T, Rancurel C, Brumer H, Coutinho PM, and Henrissat B. (2010). A hierarchical classification of polysaccharide lyases for glycogenomics. Biochem J. 2010;432(3):437-44. DOI:10.1042/BJ20101185 |
- Thomas F, Lundqvist LC, Jam M, Jeudy A, Barbeyron T, Sandström C, Michel G, and Czjzek M. (2013). Comparative characterization of two marine alginate lyases from Zobellia galactanivorans reveals distinct modes of action and exquisite adaptation to their natural substrate. J Biol Chem. 2013;288(32):23021-37. DOI:10.1074/jbc.M113.467217 |