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| + | '''22 February 2019:''' ''Starch-active LPMOs:'' '''[[User:Glyn Hemsworth|Glyn Hemsworth]]''' recently completed the '''[[Auxiliary Activity Family 13]]''' page, which was [[Curator Approved]] by [[Responsible Curator]] '''[[User:Gideon Davies|Gideon Davies]]''' today. '''[[AA13]]''' was first identified in 2014 and is notable as the first lytic polysaccharide mono-oxygenase (LPMO) family that is active on alpha-glycosidic bonds, ''viz.'' those in amylose (starch). Overall, LPMOs are an intriguing group of copper-dependent oxidases that open-up insoluble polysaccharide substrates for increased attack by [[glycoside hydrolases]]. ''Read more about '''[[AA13]]''' and related beta-active LPMOs ([[AA9]], [[AA10]], [[AA11]], AA14, & AA15) on their respective [[Auxiliary Activity Families|CAZypedia pages]] and at the [http://www.cazy.org/Auxiliary-Activities.html CAZy Database].'' | ||
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'''4 February 2019:''' ''CAZypedia's first CE page!'' Today [[Responsible Curator]] '''[[User:Michael Suits|Michael Suits]]''' approved the '''[[Carbohydrate Esterase Family 4]]''' page [[author]]ed by graduate student '''[[User:Alex Anderson|Alex Anderson]]''', thereby marking a new milestone ''CAZypedia's'' [[CAZypedia:History|history]]. [[:Category:Carbohydrate Esterase Families|Carbohydrate Esterases (CEs)]] catalyze the de-''O''-acylation or de-''N''-acylation of saccharides (the latter are formally amidases), and '''[[CE4]]''' contains members with either activity, ''e.g.'' acetylxylan esterases and peptidoglycan deacetylases. '''[[CE4]]''' members thus play diverse biological roles in nature. ''Learn more about the structure and mechanism of these metal-dependent de-acylases [[CE4|here]]''. | '''4 February 2019:''' ''CAZypedia's first CE page!'' Today [[Responsible Curator]] '''[[User:Michael Suits|Michael Suits]]''' approved the '''[[Carbohydrate Esterase Family 4]]''' page [[author]]ed by graduate student '''[[User:Alex Anderson|Alex Anderson]]''', thereby marking a new milestone ''CAZypedia's'' [[CAZypedia:History|history]]. [[:Category:Carbohydrate Esterase Families|Carbohydrate Esterases (CEs)]] catalyze the de-''O''-acylation or de-''N''-acylation of saccharides (the latter are formally amidases), and '''[[CE4]]''' contains members with either activity, ''e.g.'' acetylxylan esterases and peptidoglycan deacetylases. '''[[CE4]]''' members thus play diverse biological roles in nature. ''Learn more about the structure and mechanism of these metal-dependent de-acylases [[CE4|here]]''. | ||
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'''27 November 2018:''' ''Remember, remember... an end of November new CAZypedia CBM family page.'' The type C L-rhamnose binding [[CBM67]] family is now on-line in CAZypedia. '''[[User:Satoshi Kaneko|Satoshi Kaneko]]''' authored the page and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. ''Learn more about the structure and function of the [[CBM67]] family on its CAZypedia [[CBM67|page]]''. | '''27 November 2018:''' ''Remember, remember... an end of November new CAZypedia CBM family page.'' The type C L-rhamnose binding [[CBM67]] family is now on-line in CAZypedia. '''[[User:Satoshi Kaneko|Satoshi Kaneko]]''' authored the page and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. ''Learn more about the structure and function of the [[CBM67]] family on its CAZypedia [[CBM67|page]]''. | ||
Revision as of 08:31, 22 February 2019
22 February 2019: Starch-active LPMOs: Glyn Hemsworth recently completed the Auxiliary Activity Family 13 page, which was Curator Approved by Responsible Curator Gideon Davies today. AA13 was first identified in 2014 and is notable as the first lytic polysaccharide mono-oxygenase (LPMO) family that is active on alpha-glycosidic bonds, viz. those in amylose (starch). Overall, LPMOs are an intriguing group of copper-dependent oxidases that open-up insoluble polysaccharide substrates for increased attack by glycoside hydrolases. Read more about AA13 and related beta-active LPMOs (AA9, AA10, AA11, AA14, & AA15) on their respective CAZypedia pages and at the CAZy Database.
4 February 2019: CAZypedia's first CE page! Today Responsible Curator Michael Suits approved the Carbohydrate Esterase Family 4 page authored by graduate student Alex Anderson, thereby marking a new milestone CAZypedia's history. Carbohydrate Esterases (CEs) catalyze the de-O-acylation or de-N-acylation of saccharides (the latter are formally amidases), and CE4 contains members with either activity, e.g. acetylxylan esterases and peptidoglycan deacetylases. CE4 members thus play diverse biological roles in nature. Learn more about the structure and mechanism of these metal-dependent de-acylases here.
27 November 2018: Remember, remember... an end of November new CAZypedia CBM family page. The type C L-rhamnose binding CBM67 family is now on-line in CAZypedia. Satoshi Kaneko authored the page and Harry Gilbert acted as responsible curator. Learn more about the structure and function of the CBM67 family on its CAZypedia page.
23 November 2018: Welcome to the CAZypedia fold CBM49! The crystalline cellulose-binding CBM49 CAZypedia page was authored by Breeanna Urbanowicz and Elizabeth Ficko-Blean. Breeanna Urbanowicz also acted as responsible curator. There is experimental evidence that rice CBM49 is cleaved post-translationally in vivo which probably plays an important role in plant growth. Find out more about the functionally interesting family 49 CBMs here.
11 October 2018: Fall ushers in a new CAZypedia CBM family page. The chitin-binding and lytic polysaccharide monooxygenase associated CBM73 family is described in detail. Zarah Forsberg authored the page and Gustav Vaaje-Kolstad acted as responsible curator. Learn more about the CBM73 family on its CAZypedia page.
24 September 2018: Revenge of the Ruminococci Part Deux. Two more CBM families from Ruminococcal bacteria are ready for reading. The CBM79 and CBM80 CAZypedia pages were authored by Immacolata Venditto and Harry Gilbert acted as responsible curator. These CBMs are important for enzyme targeting but also for targeting the entire cellulosome complex to substrate. More information on the CBM79 and CBM80 families can be found on their respective CAZypedia pages.