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Difference between revisions of "User:Marie-Line Garron"
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I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases on which I wrote two reviews. | I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases on which I wrote two reviews. | ||
Revision as of 13:17, 15 June 2020
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases on which I wrote two reviews.
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at AFMB laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the CAZy database. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.
Reviews
- Garron ML and Henrissat B. (2019). The continuing expansion of CAZymes and their families. Curr Opin Chem Biol. 2019;53:82-87. DOI:10.1016/j.cbpa.2019.08.004 |
- Garron ML and Cygler M. (2014). Uronic polysaccharide degrading enzymes. Curr Opin Struct Biol. 2014;28:87-95. DOI:10.1016/j.sbi.2014.07.012 |
- Garron ML and Cygler M. (2010). Structural and mechanistic classification of uronic acid-containing polysaccharide lyases. Glycobiology. 2010;20(12):1547-73. DOI:10.1093/glycob/cwq122 |
Publications
- Turbe-Doan A, Record E, Lombard V, Kumar R, Levasseur A, Henrissat B, and Garron ML. (2019). Trichoderma reesei Dehydrogenase, a Pyrroloquinoline Quinone-Dependent Member of Auxiliary Activity Family 12 of the Carbohydrate-Active Enzymes Database: Functional and Structural Characterization. Appl Environ Microbiol. 2019;85(24). DOI:10.1128/AEM.00964-19 |
- Henrissat B and Garron ML. (2017). How a Glycoside Hydrolase Recognizes a Helical Polyglucan. Structure. 2017;25(9):1319-1321. DOI:10.1016/j.str.2017.08.004 |
- Ulaganathan T, Shi R, Yao D, Gu RX, Garron ML, Cherney M, Tieleman DP, Sterner E, Li G, Li L, Linhardt RJ, and Cygler M. (2017). Conformational flexibility of PL12 family heparinases: structure and substrate specificity of heparinase III from Bacteroides thetaiotaomicron (BT4657). Glycobiology. 2017;27(2):176-187. DOI:10.1093/glycob/cww096 |
- Lafond M, Sulzenbacher G, Freyd T, Henrissat B, Berrin JG, and Garron ML. (2016). The Quaternary Structure of a Glycoside Hydrolase Dictates Specificity toward β-Glucans. J Biol Chem. 2016;291(13):7183-94. DOI:10.1074/jbc.M115.695999 |
- Shaya D, Zhao W, Garron ML, Xiao Z, Cui Q, Zhang Z, Sulea T, Linhardt RJ, and Cygler M. (2010). Catalytic mechanism of heparinase II investigated by site-directed mutagenesis and the crystal structure with its substrate. J Biol Chem. 2010;285(26):20051-61. DOI:10.1074/jbc.M110.101071 |
- Zhao W, Garron ML, Yang B, Xiao Z, Esko JD, Cygler M, and Linhardt RJ. (2011). Asparagine 405 of heparin lyase II prevents the cleavage of glycosidic linkages proximate to a 3-O-sulfoglucosamine residue. FEBS Lett. 2011;585(15):2461-6. DOI:10.1016/j.febslet.2011.06.023 |
- Han YH, Garron ML, Kim HY, Kim WS, Zhang Z, Ryu KS, Shaya D, Xiao Z, Cheong C, Kim YS, Linhardt RJ, Jeon YH, and Cygler M. (2009). Structural snapshots of heparin depolymerization by heparin lyase I. J Biol Chem. 2009;284(49):34019-27. DOI:10.1074/jbc.M109.025338 |
- Xiao Z, Bergeron H, Grosse S, Beauchemin M, Garron ML, Shaya D, Sulea T, Cygler M, and Lau PC. (2008). Improvement of the thermostability and activity of a pectate lyase by single amino acid substitutions, using a strategy based on melting-temperature-guided sequence alignment. Appl Environ Microbiol. 2008;74(4):1183-9. DOI:10.1128/AEM.02220-07 |