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Difference between revisions of "User:Mario Murakami"
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Mario Murakami is the scientific director of the Brazilian Biorenewables National Laboratory (since 2018) and former coordinator of the macromolecular crystallography village at the Brazilian National Center for Research in Energy and Materials (2010-2017). He obtained Ph.D. degree in molecular biophysics (2006) from the State University of São Paulo with a split Ph.D. at the University of Hamburg and German Electron Synchrotron DESY. He worked with the structural elucidation of macromolecular complexes involved in the inhibition and activation of enzymes during his post-docs at UNESP and Rutgers University. His current research interests encompass the discovery and mechanistic understanding of CAZymes and the genetic engineering of filamentous fungi for enzyme production. He has contributed to structure and function studies of CAZymes from families [[GH1]] <cite>Giuseppe2012, Crespim2016, Santos2016, Zanphorlin2016, Toyama2018, Santos2019</cite>, [[GH2]] <cite>Domingues2018</cite>, [[GH5]] <cite>Santos2012a, Santos2012b, Alvarez2013a, Santos2015, Ruiz2016, Rosa2019</cite>, [[GH7]] <cite>Segato2012</cite>, [[GH8]] <cite>Scapin2017</cite>, [[GH10]] <cite>Santos2010, Alvarez2013b, Santos2014a</cite>, [[GH11]] <cite>Murakami2005, Ribeiro2011, Diogo2015, Hoffmam2016 </cite>, [[GH12]] <cite>Damasio2012, Furtado2015, Segato2017</cite>, [[GH16]] <cite>Cota2011, Cota2013</cite>, [[GH26]] <cite>Mandelli2020</cite>, [[GH39]] <cite>Santos2012c, Morais2020</cite>, [[GH42]] <cite>Godoy2016</cite>, [[GH43]] <cite>Santos2014b, Diogo2015, Zanphorlin2019</cite>, [[GH45]] <cite>Berto2019</cite>, [[GH51]] <cite>Souza2011, Santos2018</cite>, [[GH54]] <cite>Goncalves2012</cite>, [[GH57]] <cite>Santos2011</cite>, [[GH128]] <cite>Santos2020</cite>and [[AA9]] <cite>Correa2019</cite>. Recently, his group rationally engineered a publicly available strain (''Trichoderma reesei'' RUT-C30), which can secrete more than 80 g/L of proteins, mostly CAZymes, using a low-cost and byproduct-based bioprocess <cite>Fonseca2020</cite>. | Mario Murakami is the scientific director of the Brazilian Biorenewables National Laboratory (since 2018) and former coordinator of the macromolecular crystallography village at the Brazilian National Center for Research in Energy and Materials (2010-2017). He obtained Ph.D. degree in molecular biophysics (2006) from the State University of São Paulo with a split Ph.D. at the University of Hamburg and German Electron Synchrotron DESY. He worked with the structural elucidation of macromolecular complexes involved in the inhibition and activation of enzymes during his post-docs at UNESP and Rutgers University. His current research interests encompass the discovery and mechanistic understanding of CAZymes and the genetic engineering of filamentous fungi for enzyme production. He has contributed to structure and function studies of CAZymes from families [[GH1]] <cite>Giuseppe2012, Crespim2016, Santos2016, Zanphorlin2016, Toyama2018, Santos2019</cite>, [[GH2]] <cite>Domingues2018</cite>, [[GH5]] <cite>Santos2012a, Santos2012b, Alvarez2013a, Santos2015, Ruiz2016, Rosa2019</cite>, [[GH7]] <cite>Segato2012</cite>, [[GH8]] <cite>Scapin2017</cite>, [[GH10]] <cite>Santos2010, Alvarez2013b, Santos2014a</cite>, [[GH11]] <cite>Murakami2005, Ribeiro2011, Diogo2015, Hoffmam2016 </cite>, [[GH12]] <cite>Damasio2012, Furtado2015, Segato2017</cite>, [[GH16]] <cite>Cota2011, Cota2013</cite>, [[GH26]] <cite>Mandelli2020</cite>, [[GH39]] <cite>Santos2012c, Morais2020</cite>, [[GH42]] <cite>Godoy2016</cite>, [[GH43]] <cite>Santos2014b, Diogo2015, Zanphorlin2019</cite>, [[GH45]] <cite>Berto2019</cite>, [[GH51]] <cite>Souza2011, Santos2018</cite>, [[GH54]] <cite>Goncalves2012</cite>, [[GH57]] <cite>Santos2011</cite>, [[GH128]] <cite>Santos2020</cite>and [[AA9]] <cite>Correa2019</cite>. Recently, his group rationally engineered a publicly available strain (''Trichoderma reesei'' RUT-C30), which can secrete more than 80 g/L of proteins, mostly CAZymes, using a low-cost and byproduct-based bioprocess <cite>Fonseca2020</cite>. | ||
Revision as of 11:02, 18 June 2020
Mario Murakami is the scientific director of the Brazilian Biorenewables National Laboratory (since 2018) and former coordinator of the macromolecular crystallography village at the Brazilian National Center for Research in Energy and Materials (2010-2017). He obtained Ph.D. degree in molecular biophysics (2006) from the State University of São Paulo with a split Ph.D. at the University of Hamburg and German Electron Synchrotron DESY. He worked with the structural elucidation of macromolecular complexes involved in the inhibition and activation of enzymes during his post-docs at UNESP and Rutgers University. His current research interests encompass the discovery and mechanistic understanding of CAZymes and the genetic engineering of filamentous fungi for enzyme production. He has contributed to structure and function studies of CAZymes from families GH1 [1, 2, 3, 4, 5, 6], GH2 [7], GH5 [8, 9, 10, 11, 12, 13], GH7 [14], GH8 [15], GH10 [16, 17, 18], GH11 [19, 20, 21, 22], GH12 [23, 24, 25], GH16 [26, 27], GH26 [28], GH39 [29, 30], GH42 [31], GH43 [21, 32, 33], GH45 [34], GH51 [35, 36], GH54 [37], GH57 [38], GH128 [39]and AA9 [40]. Recently, his group rationally engineered a publicly available strain (Trichoderma reesei RUT-C30), which can secrete more than 80 g/L of proteins, mostly CAZymes, using a low-cost and byproduct-based bioprocess [41].
Selected publications
Santos CR, Costa PACR, Vieira PS, Gonzalez SET, Correa TLR, Lima EA, Mandelli F, Pirolla RAS, Domingues MN, Cabral L, Martins MP, Cordeiro RL, Junior AT, Souza BP, Prates ÉT, Gozzo FC, Persinoti GF, Skaf MS, and Murakami MT. (2020) Structural insights into β-1,3-glucan cleavage by a glycoside hydrolase family. Nat Chem Biol. DOI:10.1038/s41589-020-0554-5 HubMed
Fonseca LM, Parreiras LS, and Murakami MT. (2020) Rational engineering of the Trichoderma reesei RUT-C30 strain into an industrially relevant platform for cellulase production. Biotechnol Biofuels. 13, 93. DOI:10.1186/s13068-020-01732-w HubMed
Corrêa TLR, Júnior AT, Wolf LD, Buckeridge MS, Dos Santos LV, and Murakami MT. (2019) An actinobacteria lytic polysaccharide monooxygenase acts on both cellulose and xylan to boost biomass saccharification. Biotechnol Biofuels. 12, 117. DOI:10.1186/s13068-019-1449-0 HubMed
Crystal structures
List of publications
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- Domingues MN, Souza FHM, Vieira PS, de Morais MAB, Zanphorlin LM, Dos Santos CR, Pirolla RAS, Honorato RV, de Oliveira PSL, Gozzo FC, and Murakami MT. (2018). Structural basis of exo-β-mannanase activity in the GH2 family. J Biol Chem. 2018;293(35):13636-13649. DOI:10.1074/jbc.RA118.002374 |
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- Dos Santos CR, Cordeiro RL, Wong DW, and Murakami MT. (2015). Structural basis for xyloglucan specificity and α-d-Xylp(1 → 6)-D-Glcp recognition at the -1 subsite within the GH5 family. Biochemistry. 2015;54(10):1930-42. DOI:10.1021/acs.biochem.5b00011 |
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- Santos CR, Costa PACR, Vieira PS, Gonzalez SET, Correa TLR, Lima EA, Mandelli F, Pirolla RAS, Domingues MN, Cabral L, Martins MP, Cordeiro RL, Junior AT, Souza BP, Prates ÉT, Gozzo FC, Persinoti GF, Skaf MS, and Murakami MT. (2020). Structural insights into β-1,3-glucan cleavage by a glycoside hydrolase family. Nat Chem Biol. 2020;16(8):920-929. DOI:10.1038/s41589-020-0554-5 |
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