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Difference between revisions of "Carbohydrate Binding Module Family 8"
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== Ligand specificities == | == Ligand specificities == | ||
− | DdCBM8, from the slime mold ''Dictyostelium discoideum'' binds insoluble forms of cellulose and glucomannan, there is no evidence for binding to oligosaccharides <cite>Liberato2022</cite> | + | DdCBM8, from the slime mold ''Dictyostelium discoideum'' binds insoluble forms of cellulose and glucomannan, there is no evidence for binding to oligosaccharides <cite>Liberato2022</cite>. It appears to be broadly specific with both [[Carbohydrate-binding_modules#Types|type A]] and [[Carbohydrate-binding_modules#Types|type B]] CBM characteristics. |
− | |||
== Structural Features == | == Structural Features == |
Revision as of 08:40, 29 April 2024
This page is currently under construction. This means that the Responsible Curator has deemed that the page's content is not quite up to CAZypedia's standards for full public consumption. All information should be considered to be under revision and may be subject to major changes.
CAZy DB link | |
http://www.cazy.org/CBM08.html |
Ligand specificities
DdCBM8, from the slime mold Dictyostelium discoideum binds insoluble forms of cellulose and glucomannan, there is no evidence for binding to oligosaccharides [1]. It appears to be broadly specific with both type A and type B CBM characteristics.
Structural Features
Content in this section should include, in paragraph form, a description of:
- Fold: Structural fold (beta trefoil, beta sandwich, etc.)
- Type: Include here Type A, B, or C and properties
- Features of ligand binding: Describe CBM binding pocket location (Side or apex) important residues for binding (W, Y, F, subsites), interact with reducing end, non-reducing end, planar surface or within polysaccharide chains. Include examples pdb codes. Metal ion dependent. Etc.
Functionalities
Content in this section should include, in paragraph form, a description of:
- Functional role of CBM: Describe common functional roles such as targeting, disruptive, anchoring, proximity/position on substrate.
- Most Common Associated Modules: 1. Glycoside Hydrolase Activity; 2. Additional Associated Modules (other CBM, FNIII, cohesin, dockerins, expansins, etc.)
- Novel Applications: Include here if CBM has been used to modify another enzyme, or if a CBM was used to label plant/mammalian tissues? Etc.
Family Firsts
- First Identified
- Insert archetype here, possibly including very brief synopsis.
- First Structural Characterization
- The first crystal structures are from DdCBM8, from the slime mold Dictyostelium discoideum [1], see 7T7Y and 7T7Z.