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Difference between revisions of "Glycoside Hydrolase Family 135"
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== Substrate specificities == | == Substrate specificities == | ||
| − | + | A single report has disclosed a [[glycoside hydrolase]] with the ability to degrade a heteropolysaccharide galactosaminogalactan (GAG) <cite>Bamford2015</cite>. GAG is produced by ''Aspergillus fumigatus'' as an exopolysaccharide, which is α-1,4- linked galactose, N-acetylgalactosamine, and galactosamine residues, and which is found in both a secreted form and bound to the cell wall of hyphae. | |
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== Kinetics and Mechanism == | == Kinetics and Mechanism == | ||
Revision as of 18:28, 29 October 2016
This page is currently under construction. This means that the Responsible Curator has deemed that the page's content is not quite up to CAZypedia's standards for full public consumption. All information should be considered to be under revision and may be subject to major changes.
- Author: ^^^Spencer Williams^^^
- Responsible Curator: ^^^Spencer Williams^^^
| Glycoside Hydrolase Family GH135 | |
| Clan | none |
| Mechanism | unknown |
| Active site residues | known/not known |
| CAZy DB link | |
| https://www.cazy.org/GH135.html | |
Substrate specificities
A single report has disclosed a glycoside hydrolase with the ability to degrade a heteropolysaccharide galactosaminogalactan (GAG) [1]. GAG is produced by Aspergillus fumigatus as an exopolysaccharide, which is α-1,4- linked galactose, N-acetylgalactosamine, and galactosamine residues, and which is found in both a secreted form and bound to the cell wall of hyphae.
Kinetics and Mechanism
Content is to be added here.
Catalytic Residues
Content is to be added here.
Three-dimensional structures
Content is to be added here.
Family Firsts
- First stereochemistry determination
- Unknown.
- First catalytic nucleophile identification
- Unknown.
- First general acid/base residue identification
- Unknown.
- First 3-D structure
- Sph3 from Aspergillus clavatus [1].
References
- Bamford NC, Snarr BD, Gravelat FN, Little DJ, Lee MJ, Zacharias CA, Chabot JC, Geller AM, Baptista SD, Baker P, Robinson H, Howell PL, and Sheppard DC. (2015). Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus. J Biol Chem. 2015;290(46):27438-50. DOI:10.1074/jbc.M115.679050 |