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Difference between revisions of "Glycoside Hydrolase Family 6"
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Harry Brumer (talk | contribs) (Created page with '* Author: ^^^Gideon Davies^^^ * Responsible Curator: ^^^Gideon Davies^^^ ---- <!-- The data in the table below should be updated by the Author/Curator according to curr…') |
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| Line 10: | Line 10: | ||
|- | |- | ||
|'''Clan''' | |'''Clan''' | ||
| − | | | + | |none |
|- | |- | ||
|'''Mechanism''' | |'''Mechanism''' | ||
| − | | | + | |inverting |
|- | |- | ||
|'''Active site residues''' | |'''Active site residues''' | ||
| − | |known | + | |acid known, base debated |
|- | |- | ||
|{{Hl2}} colspan="2" align="center" |'''CAZy DB link''' | |{{Hl2}} colspan="2" align="center" |'''CAZy DB link''' | ||
| Line 27: | Line 27: | ||
== Substrate specificities == | == Substrate specificities == | ||
| − | + | Endoglucanases (EC 3.2.1.4) and cellobiohydrolases (EC 3.2.1.91)only. Both classes of enzyme active on cellulose / beta 1,4 glucans. | |
| − | |||
| Line 48: | Line 47: | ||
;First catalytic nucleophile identification: Cite some reference here, with a ''short'' (1-2 senetence) explanation <cite>4</cite>. | ;First catalytic nucleophile identification: Cite some reference here, with a ''short'' (1-2 senetence) explanation <cite>4</cite>. | ||
;First general acid/base residue identification: Cite some reference here, with a ''short'' (1-2 senetence) explanation <cite>2</cite>. | ;First general acid/base residue identification: Cite some reference here, with a ''short'' (1-2 senetence) explanation <cite>2</cite>. | ||
| − | ;First 3-D structure: | + | ;First 3-D structure: The Trichoderma reesei (the organism now known as ''Hypocrea jecorina'') cellobiohydrolase II by the Jones group <cite>Rouvinen1990</cite>. |
== References == | == References == | ||
<biblio> | <biblio> | ||
| − | # | + | #Rouvinen1990 pmid=2377893 |
#2 pmid=9312086 | #2 pmid=9312086 | ||
#3 isbn=978-0-240-52118-3 | #3 isbn=978-0-240-52118-3 | ||
Revision as of 08:15, 25 September 2009
- Author: ^^^Gideon Davies^^^
- Responsible Curator: ^^^Gideon Davies^^^
| Glycoside Hydrolase Family GH6 | |
| Clan | none |
| Mechanism | inverting |
| Active site residues | acid known, base debated |
| CAZy DB link | |
| http://www.cazy.org/fam/GH6.html | |
Substrate specificities
Endoglucanases (EC 3.2.1.4) and cellobiohydrolases (EC 3.2.1.91)only. Both classes of enzyme active on cellulose / beta 1,4 glucans.
Kinetics and Mechanism
Content is to be added here.
Catalytic Residues
Content is to be added here.
Three-dimensional structures
Content is to be added here.
Family Firsts
- First sterochemistry determination
- Cite some reference here, with a short (1-2 senetence) explanation [1].
- First catalytic nucleophile identification
- Cite some reference here, with a short (1-2 senetence) explanation [2].
- First general acid/base residue identification
- Cite some reference here, with a short (1-2 senetence) explanation [3].
- First 3-D structure
- The Trichoderma reesei (the organism now known as Hypocrea jecorina) cellobiohydrolase II by the Jones group [4].
References
-
Sinnott, M.L. (1990) Catalytic mechanisms of enzymic glycosyl transfer. Chem. Rev. 90, 1171-1202. DOI: 10.1021/cr00105a006
- He S and Withers SG. (1997). Assignment of sweet almond beta-glucosidase as a family 1 glycosidase and identification of its active site nucleophile. J Biol Chem. 1997;272(40):24864-7. DOI:10.1074/jbc.272.40.24864 |
- Rouvinen J, Bergfors T, Teeri T, Knowles JK, and Jones TA. (1990). Three-dimensional structure of cellobiohydrolase II from Trichoderma reesei. Science. 1990;249(4967):380-6. DOI:10.1126/science.2377893 |
[[Category:Glycoside Hydrolase Families|GHnnn]]