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Difference between revisions of "Talk:Syn/anti lateral protonation"
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'''PLEASE NOTE: If you leave a comment here, please sign it by adding four tildes (<nowiki>~~~~</nowiki>) after your post. Thanks!''' | '''PLEASE NOTE: If you leave a comment here, please sign it by adding four tildes (<nowiki>~~~~</nowiki>) after your post. Thanks!''' | ||
| − | + | Click the "+" tab to add a new discussion section... | |
[[User:Harry Brumer|Harry Brumer]] 11:10, 9 November 2009 (UTC) | [[User:Harry Brumer|Harry Brumer]] 11:10, 9 November 2009 (UTC) | ||
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[[User:Harry Brumer|Harry Brumer]] 11:12, 9 November 2009 (UTC) | [[User:Harry Brumer|Harry Brumer]] 11:12, 9 November 2009 (UTC) | ||
| − | == | + | == Three questions from Wim == |
| + | === Adding clan info === | ||
| + | ''1) May I add the clan to the family (so the first row would be called Family / Clan and the first entry would then be GH1 / A)? Because this would be very usefull if I would (later) also introduce family-entries "by similarity" (for which there is as yet no proving complexed structure) just like Heightman&Vasella did in their table, e.g. all families of clan-A are anti by similarity.'' | ||
| + | |||
| + | * I think this is a good idea, but the clan should be entered as a separate column, so the table can be sorted by Clan (where available). [[User:Harry Brumer|Harry Brumer]] 14:47, 9 November 2009 (UTC) | ||
| + | |||
| + | === alpha/beta vs. axial/equatorial === | ||
| + | ''2) At the second row (Anomeric specificity), may I add to the entries whether it is axial or equatorial? Because alpha / beta is by IUPAC-definition only for the anomeric versus D/L relationship within the Fisher projection and nothing else, thus alpha / beta is (often but) not always resp axial / equatorial in the sugar's ground state conformation, the prime example being glycosides of sialic/neuraminic acid where their ground state 2C5 is alpha-equatorial.'' | ||
| + | |||
| + | * I would suggest we stick with alpha/beta for now, since it works in 95+% of the cases (although the limitation is acknowledged). Mike's e/a notation never really achieved widespread use, and the specialist will understand the odd cases. It's best to keep things simple in the beginning. [[User:Harry Brumer|Harry Brumer]] 14:47, 9 November 2009 (UTC) | ||
| + | |||
| + | === exo-anomeric column === | ||
| + | ''The third question - but not for now - is to consider to add an extra row next to the one of the ligand, indicating if it is in or out of the exo-anomeric effect. Once I'll make-post the drawings, it will be very clear that in-anti and out-syn are connected, and indeed you can see this in several complexed structures.'' | ||
| − | + | * Let's keep this idea on hold for a bit. [[User:Harry Brumer|Harry Brumer]] 14:47, 9 November 2009 (UTC) | |
| − | [[User:Harry Brumer|Harry Brumer]] | ||
Revision as of 06:47, 9 November 2009
PLEASE NOTE: If you leave a comment here, please sign it by adding four tildes (~~~~) after your post. Thanks! Click the "+" tab to add a new discussion section... Harry Brumer 11:10, 9 November 2009 (UTC)
Page created 2009-11-09
Table outline created for further modification. Harry Brumer 11:12, 9 November 2009 (UTC)
Three questions from Wim
Adding clan info
1) May I add the clan to the family (so the first row would be called Family / Clan and the first entry would then be GH1 / A)? Because this would be very usefull if I would (later) also introduce family-entries "by similarity" (for which there is as yet no proving complexed structure) just like Heightman&Vasella did in their table, e.g. all families of clan-A are anti by similarity.
- I think this is a good idea, but the clan should be entered as a separate column, so the table can be sorted by Clan (where available). Harry Brumer 14:47, 9 November 2009 (UTC)
alpha/beta vs. axial/equatorial
2) At the second row (Anomeric specificity), may I add to the entries whether it is axial or equatorial? Because alpha / beta is by IUPAC-definition only for the anomeric versus D/L relationship within the Fisher projection and nothing else, thus alpha / beta is (often but) not always resp axial / equatorial in the sugar's ground state conformation, the prime example being glycosides of sialic/neuraminic acid where their ground state 2C5 is alpha-equatorial.
- I would suggest we stick with alpha/beta for now, since it works in 95+% of the cases (although the limitation is acknowledged). Mike's e/a notation never really achieved widespread use, and the specialist will understand the odd cases. It's best to keep things simple in the beginning. Harry Brumer 14:47, 9 November 2009 (UTC)
exo-anomeric column
The third question - but not for now - is to consider to add an extra row next to the one of the ligand, indicating if it is in or out of the exo-anomeric effect. Once I'll make-post the drawings, it will be very clear that in-anti and out-syn are connected, and indeed you can see this in several complexed structures.
- Let's keep this idea on hold for a bit. Harry Brumer 14:47, 9 November 2009 (UTC)