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Difference between revisions of "User:Tom Wennekes"
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'''Tom Wennekes''' is currently a postdoctoral fellow in [http://www.chem.ubc.ca/personnel/faculty/withers/group/ the group] of [[User:Steve_Withers| Prof. Steve Withers]] at the Department of Chemistry, The University of British Columbia. He received his Ph.D. from the Faculty of Science at Leiden University in 2008, for his research on inhibitors of glycosidases and glycosyltransferases involved in glycosphingolipid metabolism performed under the supervision of [http://biosyn.lic.leidenuniv.nl/ Prof. Hermen Overkleeft] and [http://www.amc.nl/index.cfm?sid=1266&contentitemid=118&itemid=99 Prof. Hans Aerts]. As of November 2010 he will join [http://www.orc.wur.nl/UK/ the Laboratory of Organic Chemistry] at Wageningen University as an assistant professor in Synthetic Bio-organic Chemistry and Chemical Biology. | '''Tom Wennekes''' is currently a postdoctoral fellow in [http://www.chem.ubc.ca/personnel/faculty/withers/group/ the group] of [[User:Steve_Withers| Prof. Steve Withers]] at the Department of Chemistry, The University of British Columbia. He received his Ph.D. from the Faculty of Science at Leiden University in 2008, for his research on inhibitors of glycosidases and glycosyltransferases involved in glycosphingolipid metabolism performed under the supervision of [http://biosyn.lic.leidenuniv.nl/ Prof. Hermen Overkleeft] and [http://www.amc.nl/index.cfm?sid=1266&contentitemid=118&itemid=99 Prof. Hans Aerts]. As of November 2010 he will join [http://www.orc.wur.nl/UK/ the Laboratory of Organic Chemistry] at Wageningen University as an assistant professor in Synthetic Bio-organic Chemistry and Chemical Biology. | ||
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| + | ---- | ||
| + | <biblio> | ||
| + | #REF1 pmid=20000679 | ||
| + | #REF2 pmid=19862781 | ||
| + | #REF3 pmid=17392268 | ||
| + | #REF4 pmid=17287460 | ||
| + | #REF5 pmid=17243712 | ||
| + | #REF6 pmid=17105727 | ||
| + | </biblio> | ||
Revision as of 15:45, 18 August 2010
Tom Wennekes is currently a postdoctoral fellow in the group of Prof. Steve Withers at the Department of Chemistry, The University of British Columbia. He received his Ph.D. from the Faculty of Science at Leiden University in 2008, for his research on inhibitors of glycosidases and glycosyltransferases involved in glycosphingolipid metabolism performed under the supervision of Prof. Hermen Overkleeft and Prof. Hans Aerts. As of November 2010 he will join the Laboratory of Organic Chemistry at Wageningen University as an assistant professor in Synthetic Bio-organic Chemistry and Chemical Biology.
- Wennekes T, Meijer AJ, Groen AK, Boot RG, Groener JE, van Eijk M, Ottenhoff R, Bijl N, Ghauharali K, Song H, O'Shea TJ, Liu H, Yew N, Copeland D, van den Berg RJ, van der Marel GA, Overkleeft HS, and Aerts JM. (2010). Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. J Med Chem. 2010;53(2):689-98. DOI:10.1021/jm901281m |
- Wennekes T, van den Berg RJ, Boot RG, van der Marel GA, Overkleeft HS, and Aerts JM. (2009). Glycosphingolipids--nature, function, and pharmacological modulation. Angew Chem Int Ed Engl. 2009;48(47):8848-69. DOI:10.1002/anie.200902620 |
- Bussink AP, van Swieten PF, Ghauharali K, Scheij S, van Eijk M, Wennekes T, van der Marel GA, Boot RG, Aerts JM, and Overkleeft HS. (2007). N-azidoacetylmannosamine-mediated chemical tagging of gangliosides. J Lipid Res. 2007;48(6):1417-21. DOI:10.1194/jlr.C700006-JLR200 |
- Aerts JM, Ottenhoff R, Powlson AS, Grefhorst A, van Eijk M, Dubbelhuis PF, Aten J, Kuipers F, Serlie MJ, Wennekes T, Sethi JK, O'Rahilly S, and Overkleeft HS. (2007). Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity. Diabetes. 2007;56(5):1341-9. DOI:10.2337/db06-1619 |
- Wennekes T, van den Berg RJ, Donker W, van der Marel GA, Strijland A, Aerts JM, and Overkleeft HS. (2007). Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man. J Org Chem. 2007;72(4):1088-97. DOI:10.1021/jo061280p |
- Boot RG, Verhoek M, Donker-Koopman W, Strijland A, van Marle J, Overkleeft HS, Wennekes T, and Aerts JM. (2007). Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2. J Biol Chem. 2007;282(2):1305-12. DOI:10.1074/jbc.M610544200 |