CAZypedia celebrates the life of Senior Curator Emeritus Harry Gilbert, a true giant in the field, who passed away in September 2025.
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User:Scott Mazurkewich
Researcher at the Department of Biology and Biological Engineering, Chalmers University of Technology.
Background
Scott obtained both his BSc and PhD from the University of Guelph in Canada. His PhD work, completed under the supervision of Stephen Seah, was on structure-function studies of enzymes involved in the metabolism of aromatic lignin fragments in Pseudomonas [1, 2, 3]. Shortly after completing his PhD studies, he started a post-doctoral research position with Johan Larsbrink at Chalmers University. There he has been working collaboratively with Jenny Arnling Bååth and Leila Lo Leggio on structure-function studies of bacterial CE15 members.
Selected papers
- Wang W, Mazurkewich S, Kimber MS, and Seah SY. (2010). Structural and kinetic characterization of 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolase, a protocatechuate degradation enzyme evolutionarily convergent with the HpaI and DmpG pyruvate aldolases. J Biol Chem. 2010;285(47):36608-15. DOI:10.1074/jbc.M110.159509 |
- Mazurkewich S, Wang W, and Seah SY. (2014). Biochemical and structural analysis of RraA proteins to decipher their relationships with 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolases. Biochemistry. 2014;53(3):542-53. DOI:10.1021/bi401486g |
- Mazurkewich S, Brott AS, Kimber MS, and Seah SY. (2016). Structural and Kinetic Characterization of the 4-Carboxy-2-hydroxymuconate Hydratase from the Gallate and Protocatechuate 4,5-Cleavage Pathways of Pseudomonas putida KT2440. J Biol Chem. 2016;291(14):7669-86. DOI:10.1074/jbc.M115.682054 |
- Arnling Bååth J, Mazurkewich S, Knudsen RM, Poulsen JN, Olsson L, Lo Leggio L, and Larsbrink J. (2018). Biochemical and structural features of diverse bacterial glucuronoyl esterases facilitating recalcitrant biomass conversion. Biotechnol Biofuels. 2018;11:213. DOI:10.1186/s13068-018-1213-x |
- Hao MS, Mazurkewich S, Li H, Kvammen A, Saha S, Koskela S, Inman AR, Nakajima M, Tanaka N, Nakai H, Brändén G, Bulone V, Larsbrink J, and McKee LS. (2024). Structural and biochemical analysis of family 92 carbohydrate-binding modules uncovers multivalent binding to β-glucans. Nat Commun. 2024;15(1):3429. DOI:10.1038/s41467-024-47584-y |
- Mazurkewich S, Widén T, Karlsson H, Evenäs L, Ramamohan P, Wohlert J, Brändén G, and Larsbrink J. (2025). Structural and biochemical basis for activity of Aspergillus nidulans α-1,3-glucanases from glycoside hydrolase family 71. Commun Biol. 2025;8(1):1298. DOI:10.1038/s42003-025-08696-3 |