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Glycoside Hydrolase Family 61
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This family has been deleted from the CAZy classification. A specific explanation may be found below.
GH61 is a deleted family
The enzymes in this family were originally classified as a glycoside hydrolases (GH61) based on very weak endo-1,4-beta-D-glucanase activity in one family member. They are now reclassified into Auxiliary Activity Family 9 in CAZy [1]. AA9 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); cleavage of cellulose chains with oxidation of various carbons (C-1, C-4 and C-6) has been reported several times in the literature (see [2] and references therein).
References
- Levasseur A, Drula E, Lombard V, Coutinho PM, and Henrissat B. (2013). Expansion of the enzymatic repertoire of the CAZy database to integrate auxiliary redox enzymes. Biotechnol Biofuels. 2013;6(1):41. DOI:10.1186/1754-6834-6-41 |
- Hemsworth GR, Davies GJ, and Walton PH. (2013). Recent insights into copper-containing lytic polysaccharide mono-oxygenases. Curr Opin Struct Biol. 2013;23(5):660-8. DOI:10.1016/j.sbi.2013.05.006 |
| CAZy DB links | |
| https://www.cazy.org/AA9.html | |
| https://www.cazy.org/GH61.html |