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Polysaccharide Lyases
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- Author: ^^^Michael Suits^^^ and ^^^Wade Abbott^^^
- Responsible Curator: ^^^Spencer Williams^^^
Introduction
Polysaccharide lyases (PLs) cleave uronic acid-containing polysaccharides via a β-elimination mechanism to generate an unsaturated hexenuronic acid residue and a new reducing end at the point of cleavage. PLs have been grouped into families and subfamilies within the Carbohydrate-Active Enzyme (CAZy) framework [1]. Please see the following reviews on PL classification, specificities, and structures [1, 2]
References
- Lombard V, Bernard T, Rancurel C, Brumer H, Coutinho PM, and Henrissat B. (2010). A hierarchical classification of polysaccharide lyases for glycogenomics. Biochem J. 2010;432(3):437-44. DOI:10.1042/BJ20101185 |
- Garron ML and Cygler M. (2010). Structural and mechanistic classification of uronic acid-containing polysaccharide lyases. Glycobiology. 2010;20(12):1547-73. DOI:10.1093/glycob/cwq122 |