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User:Wade Abbott

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Dr. Abbott received his PhD from the University of Victoria in 2005. He then studied the molecular basis of protein-carbohydrate interactions under Dr. ^^^Alisdair Boraston^^^ at the University of Victoria. In 2008, Dr. Abbott joined Dr. ^^^Harry Gilbert^^^ at the Complex Carbohydrate Research Centre, at the University of Georgia where he investigated the functional genomics of carbohydrate utilization pathways from intestinal bacteria. Currently, Dr. Abbott is a Research Scientist for Agriculture and Agri-Food Canada based at the Lethbridge Research Centre and Adjunct Professor at the University of Lethbridge. His research program investigates the mechanisms of complex carbohydrate modification by intestinal bacteria, and is developing applications for carbohydrates in animal agriculture and human intestinal health.

I have contributed to structure-function studies of the following CAZyme Families:

Glycoside Hydrolases

  • GH20 Streptococcus pneumoniae exo-β-D-N-acetylglucosaminidase (SpnGH20AB/StrH) [1, 2].
  • GH28 Yersinia enterocolitica exopolygalacturonase (YeGH28) [3]. *Family First
  • GH85 Streptococcus pneumoniae endo-β-D-glucosaminidase D (SpGH85/EndoD) [4]. *Family First

Polysaccharide Lyases

  • PL2 Yersinia enterocolitica perplasmic pectate lyase (YePL2A) [5]. Paenibacillus sp. Y412MC10 Cytoplasmic endolytic pectate lyase (PaePL2) [6]. *Family First
  • PL22 Yersinia enterocolitica Cytoplasmic oligogalacturonate lyase (YePL22/Ogl) [7]. *Family First

Carbohydrate Binding Modules

  • CBM6 [8]
  • CBM32 Yersinia enterocolitica polygalacturonic acid binding protein (YeCBM32) [9]. Streptococcus pneumoniae EndoD CBM (SpnCBM32) [10].
  • CBM35 [11]
  • CBM51 Clostridium perfringens blood group binding CBMs (GH95CBM51 and GH98CBM51) [12]

Carbohydrate Esterases

  • CE8 Yersinia enterocolitica pectin methylesterase [13]


References <biblio> #Abbott2007a pmid=17397864

  1. Abbott2007b pmid=17292916
  2. Abbott2007c pmid=17881361
  3. Finn2008 pmid=18292090
  4. Abbott2009a pmid=19181667
  5. Abbott2009b pmid=19181667
  6. Abbott2010a pmid=20851883
  7. Correia2010 pmid=20496884
  8. Abbott2011 pmid=21505233
  9. Pluvinage2011 pmid=22078560
  10. Abbott2012 pmid=22297983
  11. Pluvinage2013 pmid=23154168
  12. Abbott2013 pmid=24013861
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