Glycoside Hydrolase Family 77

This page is currently under construction. This means that the Responsible Curator has deemed that the page's content is not quite up to CAZypedia's standards for full public consumption. All information should be considered to be under revision and may be subject to major changes.

• Author: ^^^Stefan Janecek^^^
• Responsible Curator: ^^^Stefan Janecek^^^

---

Glycoside Hydrolase Family GH77
Clan	GH-H
Mechanism	retaining
Active site residues	known
CAZy DB link
https://www.cazy.org/GH77.html

Substrate specificities

Glycoside hydrolase family 77 is the member of the α-amylase clan GH-H [1], together with GH13 and GH70 [2]. The family contains only one enzyme specificity - the amylomaltase (EC 2.4.1.25), that is known as disproportionating enzyme (D-enzyme) in plants [3] or 4-α-glucanotransferase in bacteria [4] and archaeons [5]. As of June 2014, it has more than 2,000 members [1] with ~1,950 from Bacteria, and about 30 from each Archaea and Eukarya (plants and green algae).

Amylomaltase catalyses the glucan-chain transfer from one α-1,4-glucan to another α-1,4-glucan (or to 4-hydroxyl group of glucose) or within a single linear glucan molecule to produce a cyclic α-1,4-glucan with degree of polymerization starting from 17 [3, 4, 5]. Cyclodextrin glucanotransferase, a member of the α-amylase family GH13, also produces cyclic α-1,4-glucans, but with a small degree of polymerization (6-8), called cyclodextrins [6].

Catalytic Residues

Content is to be added here.

Three-dimensional structures

Content is to be added here.

Family Firsts

First stereochemistry determination

Cite some reference here, with a short (1-2 sentence) explanation.

First catalytic nucleophile identification

Cite some reference here, with a short (1-2 sentence) explanation.

First general acid/base residue identification

Cite some reference here, with a short (1-2 sentence) explanation.

First 3-D structure

Cite some reference here, with a short (1-2 sentence) explanation.

References

Error fetching PMID 11257505:
Error fetching PMID 7678257:
Error fetching PMID 10049841:
Error fetching PMID 16151092:
Error fetching PMID 19763564:
Error fetching PMID 18494783:
Error fetching PMID 10677288:
Error fetching PMID 11082203:
Error fetching PMID 23989149:
Error fetching PMID 22672337:
Error fetching PMID 21117235:
Error fetching PMID 23465909:

1. Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, and Henrissat B. (2009). The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics. Nucleic Acids Res. 2009;37(Database issue):D233-8. DOI:10.1093/nar/gkn663 |