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Glycoside Hydrolase Family 145
- Responsible Curator: ^^^Bernard Henrissat^^^
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This family has been deleted from the CAZy classification. A specific explanation may be found below.
GH145 is a deleted family
This family has been reclassified as Polysaccharide Lyase Family 42. Two members of the family from Bacteroides species were originally shown to have hydrolase activity catalyzed by a semi-conserved active site on the posterior side of the beta-propeller structure [1]. Subsequently, lyase activity on alpha-L-Rha-1,4-alpha-D-GlcA via a well-conserved active site on the anterior surface, with strong similarity to PL24 and PL25, was demonstrated in bacterial [2] and fungal [3] homologs.
References
- Munoz-Munoz J, Cartmell A, Terrapon N, Henrissat B, and Gilbert HJ. (2017). Unusual active site location and catalytic apparatus in a glycoside hydrolase family. Proc Natl Acad Sci U S A. 2017;114(19):4936-4941. DOI:10.1073/pnas.1701130114 |
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| CAZy DB links | |
| https://www.cazy.org/GH145.html | |
| https://www.cazy.org/PL42.html |