User:Wei Peng

Wei Peng obtained his Ph.D. at Tsinghua University in China with Prof. Yigong Shi and Prof. Nieng Yan. He was trained as a structural biologist using protein crystallography/cryo-EM and other tools to investigate protein functions. As a postdoc with Prof. Kim Orth at UT Southwestern Medical Center, he focused on revealing host-pathogen interaction mechanisms.

Wei and colleagues discovered that the bacterial effector protein AvrB is an unprecedented glycosyltransferase (with a fold called Fido) [1]. AvrB catalyzes the transfer of rhamnose from UDP-rhamnose to a threonine residue of its protein substrate in host cells. AvrB is the founding member of glycosyltransferases with Fido fold (GT138).

Wei contributed to studies on:

• GT138 Pseudomonas syringae rhamnosyltransferase AvrB [1]

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1. Peng W, Garcia N, Servage KA, Kohler JJ, Ready JM, Tomchick DR, Fernandez J, and Orth K. (2024). Pseudomonas effector AvrB is a glycosyltransferase that rhamnosylates plant guardee protein RIN4. Sci Adv. 2024;10(7):eadd5108. DOI:10.1126/sciadv.add5108 |