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User:Beatrice Cobucci-Ponzano
Beatrice Cobucci-Ponzano obtained her degree in Biology from the University of Naples “Federico II” Italy, in 1997, working on the beta-glycosidase (GH1) from the archaeon Sulfolobus solfataricus, under the supervision of Mosè Rossi at the Institute of Protein Biochemistry (IBP) of the italian National Research Council (CNR).
She obtained her PhD in Biochemistry and Biophisic at the University of Padua, working on the characterization of CAZymes form hyperthermophiles (GH1 and GH31) [1, 2] under the supervision of Marco Moracci at IBP.
From 2001 she is staff scientist at IBP in the group of Marco Moracci. The work focuses on the characterization and the understanding of the reaction mechanism of glycoside hydrolases, on their modification for the synthesis of glycosides (glycosynthases), and on glycosyltransferases.
She has determined the reaction mechanism and the catalytic residues of alpha-L-fucosidases (GH29). Recently, she developed a new method for the modification of this class of enzymes in efficient alpha-L-fucosynthases. This method could be of general applicability to all alpha-glycosidases.
Recently, she characterized a new archaeal beta-glycosidase that allowed the creation of the new CAZy family GH116.
Reference list <biblio>
- PMID12012341 pmid=12012341
- PMID10801892 pmid=10801892