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Talk:Glycoside Hydrolase Family 20
It should be pointed out that the X-ray structures of human Hex A and Hex B have been determined:)
1) Lemieux MJ, et al. (2006) Crystallographic Structure of Human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of G(M2) Ganglioside Hydrolysis. J Mol Biol.
2) Mark BL, et al. (2003) Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease. J Mol Biol 327(5):1093-1109.