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User:David Teze
I completed in 2012 my PhD studies focused on engineering glycoside hydrolases (GHs) into transglycosylases, particularly GH1 [1] and GH36 [2], under the supervision of professors Michel Dion and Vinh Tran.
After a few years working in a different field (radiochemistry and theoretical chemistry), I came back to the CAZymes world thanks to a postdoctoral position mentored by professor Birte Svensson (in Lyngby, close to Copenhagen, Denmark). I continued to work on engineering GHs, to turn them into transglycosylases as well as phosphorylases [3] and efficient glycosynthases. I also got more involved in completing glycoside hydrolases mechanisms, especially GH84 [3] and GH109, and started to work on glycosyltransferases.
email: <email>david.teze@gmail.com</email>
- Teze D, Hendrickx J, Czjzek M, Ropartz D, Sanejouand YH, Tran V, Tellier C, and Dion M. (2014). Semi-rational approach for converting a GH1 β-glycosidase into a β-transglycosidase. Protein Eng Des Sel. 2014;27(1):13-9. DOI:10.1093/protein/gzt057 |
- Teze D, Daligault F, Ferrières V, Sanejouand YH, and Tellier C. (2015). Semi-rational approach for converting a GH36 α-glycosidase into an α-transglycosidase. Glycobiology. 2015;25(4):420-7. DOI:10.1093/glycob/cwu124 |
- Teze D, Coines J, Raich L, Kalichuk V, Solleux C, Tellier C, André-Miral C, Svensson B, and Rovira C. (2020). A Single Point Mutation Converts GH84 O-GlcNAc Hydrolases into Phosphorylases: Experimental and Theoretical Evidence. J Am Chem Soc. 2020;142(5):2120-2124. DOI:10.1021/jacs.9b09655 |