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User:Jose Munoz
I received my BSc degree in Biochemistry in the University of Murcia (Spain) where I started to be passionate about how the enzymes work and what are the kinetic mechanisms of different kind of enzymes like oxidases, hydrolases o peptidases. To follow with my interest in enzymology, I joined the lab of Prof Francisco Garcia-Canovas in Murcia (Spain) to pursue my PhD studies in oxidases. In these studies, I characterized the kinetic mechanism of the enzyme tyrosinase, the key enzyme in the melanogenesis pathway, and tried to understand the structural and kinetic behaviour of this enzyme in its suicide inactivation process. After this stage, I moved to Newcastle Upon Tyne (U.K.) to join the lab of Prof Harry J. Gilbert where started to study how the Human Gut Microbiota can deal with different carbohydrate present in the diet focusing these studies in the enzymatic degradation of the polysaccharide Arabinogalactan from different plants such as Larch Wood, Gum Arabic or Wheat flour. This work led to the discovery of different new carbohydrate active enzymes including GH145 or PL27. Also, we have determined the recipient of keystone status of different Bacteroides species in the degradation of complex plant arabinogalactans.
At the moment, I am in Northumbria University Newcastle understanding the role of Bacteroidetes in the metabolism of different dietary arabinogalactans and the symbiotic interactions with other phyla present in the human gut.
- Munoz-Munoz J, Cartmell A, Terrapon N, Henrissat B, and Gilbert HJ. (2017). Unusual active site location and catalytic apparatus in a glycoside hydrolase family. Proc Natl Acad Sci U S A. 2017;114(19):4936-4941. DOI:10.1073/pnas.1701130114 |
- Munoz-Munoz J, Cartmell A, Terrapon N, Baslé A, Henrissat B, and Gilbert HJ. (2017). An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins. J Biol Chem. 2017;292(32):13271-13283. DOI:10.1074/jbc.M117.794578 |
- Cartmell A, Muñoz-Muñoz J, Briggs JA, Ndeh DA, Lowe EC, Baslé A, Terrapon N, Stott K, Heunis T, Gray J, Yu L, Dupree P, Fernandes PZ, Shah S, Williams SJ, Labourel A, Trost M, Henrissat B, and Gilbert HJ. (2018). A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation. Nat Microbiol. 2018;3(11):1314-1326. DOI:10.1038/s41564-018-0258-8 |