User:Tobias Tandrup

Postdoc researcher at the Technical University of Denmark.

Short biography

Tobias obtained his B.Sc. (2015) and M.Sc (2017) in Nanoscience and PhD (2021) in Crystallography from the University of Copenhagen, supervised by Leila Lo Leggio. His work focused on structural studies of GH51 arabinofuranosidases [1] and AA9 lytic polysaccharide monooxygenases [2, 3, 4, 5, 6, 7, 8]. During his PhD, he was awarded a Fulbright schorlarship towards a neutron crystallographic study with Flora Meilleur at the Oak Ridge National Laboratory, TN, USA [9]. In 2021 he joined the group of Birte Svensson, working on PL6, PL17, and PL38 alginate lyases[10, 11].

Tobias has authored or co-authored a number of entries in the Protein Data Bank.

References

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1. Zhao J, Tandrup T, Bissaro B, Barbe S, Poulsen JN, André I, Dumon C, Lo Leggio L, O'Donohue MJ, and Fauré R. (2021). Probing the determinants of the transglycosylation/hydrolysis partition in a retaining α-l-arabinofuranosidase. N Biotechnol. 2021;62:68-78. DOI:10.1016/j.nbt.2021.01.008 |
2. Frandsen KEH, Poulsen JN, Tandrup T, and Lo Leggio L. (2017). Unliganded and substrate bound structures of the cellooligosaccharide active lytic polysaccharide monooxygenase LsAA9A at low pH. Carbohydr Res. 2017;448:187-190. DOI:10.1016/j.carres.2017.03.010 |
3. Simmons TJ, Frandsen KEH, Ciano L, Tryfona T, Lenfant N, Poulsen JC, Wilson LFL, Tandrup T, Tovborg M, Schnorr K, Johansen KS, Henrissat B, Walton PH, Lo Leggio L, and Dupree P. (2017). Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates. Nat Commun. 2017;8(1):1064. DOI:10.1038/s41467-017-01247-3 |
4. Tandrup T, Frandsen KEH, Johansen KS, Berrin JG, and Lo Leggio L. (2018). Recent insights into lytic polysaccharide monooxygenases (LPMOs). Biochem Soc Trans. 2018;46(6):1431-1447. DOI:10.1042/BST20170549 |
5. Labourel A, Frandsen KEH, Zhang F, Brouilly N, Grisel S, Haon M, Ciano L, Ropartz D, Fanuel M, Martin F, Navarro D, Rosso MN, Tandrup T, Bissaro B, Johansen KS, Zerva A, Walton PH, Henrissat B, Leggio LL, and Berrin JG. (2020). A fungal family of lytic polysaccharide monooxygenase-like copper proteins. Nat Chem Biol. 2020;16(3):345-350. DOI:10.1038/s41589-019-0438-8 |
6. Tandrup T, Tryfona T, Frandsen KEH, Johansen KS, Dupree P, and Lo Leggio L. (2020). Oligosaccharide Binding and Thermostability of Two Related AA9 Lytic Polysaccharide Monooxygenases. Biochemistry. 2020;59(36):3347-3358. DOI:10.1021/acs.biochem.0c00312 |
7. Banerjee S, Muderspach SJ, Tandrup T, Frandsen KEH, Singh RK, Ipsen JØ, Hernández-Rollán C, Nørholm MHH, Bjerrum MJ, Johansen KS, and Lo Leggio L. (2022). Protonation State of an Important Histidine from High Resolution Structures of Lytic Polysaccharide Monooxygenases. Biomolecules. 2022;12(2). DOI:10.3390/biom12020194 |
8. Tandrup T, Lo Leggio L, and Meilleur F. (2023). Joint X-ray/neutron structure of Lentinus similis AA9_A at room temperature. Acta Crystallogr F Struct Biol Commun. 2023;79(Pt 1):1-7. DOI:10.1107/S2053230X22011335 |
9. Tandrup T, Muderspach SJ, Banerjee S, Santoni G, Ipsen JØ, Hernández-Rollán C, Nørholm MHH, Johansen KS, Meilleur F, and Lo Leggio L. (2022). Changes in active-site geometry on X-ray photoreduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding. IUCrJ. 2022;9(Pt 5):666-681. DOI:10.1107/S2052252522007175 |
10. Rønne ME, Madsen M, Tandrup T, Wilkens C, and Svensson B. (2023). Gut bacterial alginate degrading enzymes. Essays Biochem. 2023;67(3):387-398. DOI:10.1042/EBC20220123 |
11. Rønne ME, Tandrup T, Madsen M, Hunt CJ, Myers PN, Moll JM, Holck J, Brix S, Strube ML, Aachmann FL, Wilkens C, and Svensson B. (2023). Three alginate lyases provide a new gut Bacteroides ovatus isolate with the ability to grow on alginate. Appl Environ Microbiol. 2023;89(10):e0118523. DOI:10.1128/aem.01185-23 |