User:Zachary Armstrong

Dr. Zachary Armstrong, a native of Iqaluit, Nunavut, obtained his B.Sc. — majoring in chemistry and biochemistry — from the University of British Columbia. His final year project, performed under the guidance of Professor Steve Withers, focused on the creation of a GH11 thioglycoligase [1]. He completed his PhD at the University of British Columbia, co-supervised by Professors Steve Withers and Steven J. Hallam. This work focused on the identification of glycoside hydrolases from metagenomic sources — including the beaver gut[2],a mining bioreactor[3] and soils[4]— and the engineering of glycosynthases from metagenomes and synthetic gene libraries[5]. In 2018 he joined the group of Gideon Davies in the York Structural Biology Laboratories at the University of York as a postdoctoral research associate. His current work focuses on mechanism-based inhibitors and activity-based protein profiling of human carbohydrate processing enzymes.

He has determined the crystal structure of :

• GH164 Bacteroides salyersiae beta-mannosidase [6]

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5. Armstrong Z, Liu F, Chen H-M, Hallam SJ, Withers SG. (2019) Systematic Screening of Synthetic Gene-Encoded Enzymes for Synthesis of Modified Glycosides. ACS Catal. 53, 689-98. | DOI: 10.1021/acscatal.8b05179

6. Armstrong Z and Davies GJ. (2020). Structure and function of Bs164 β-mannosidase from Bacteroides salyersiae the founding member of glycoside hydrolase family GH164. J Biol Chem. 2020;295(13):4316-4326. DOI:10.1074/jbc.RA119.011591 |