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Difference between revisions of "Template:News"

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'''2 May 2018:''' The [[CBM65]] page has been added to the CBM CAZypedia fold. This is a small CAZy family with  two currently characterized members from an anaerobic cellulolytic ruminal bacterium.  The two [[CBM65]] members bind various beta-glucans and play an important role in enhancing enzymatic activity on substrate. The page was authored by '''[[User:Ana Luis|Ana Luis]]''' and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. ''Learn more about this CBM family [[CBM65|here]].''
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'''1 November 2024:''' ''Is this a world record? Six CAZypedia families in one fell swoop!'' The '''[[CBM47]], [[CBM70]], [[CBM96]], [[CBM105]], [[CBM106]] and [[PL44]]''' ''CAZypedia'' pages are now flipped to [[Curator Approved]] status. What do these diverse families from diverse origins with diverse binding specificities have in common? Astonishingly, at least one characterized member from each family interacts with a charged glycan! '''[[User:Wenwen Tao|Wenwen Tao]]''' authored the [[CBM47]], [[CBM96]] and [[CBM106]] pages, '''[[User:Menghui Sun|Menghui Sun]]''' authored the [[CBM70]] page, '''[[User:Guanchen Liu|Guanchen Liu]]''' authored the [[CBM105]] page and '''[[User:Jinhang Zhou|Jinhang Zhou]]''' authored the [[PL44]] page.  All this under the responsible curatorship of '''[[User:Yaoguang Chang|Yaoguang Chang]]'''. ''Dive into these diverse families on their respective ''CAZypedia'' pages: '''[[CBM47]], [[CBM70]], [[CBM96]], [[CBM105]], [[CBM106]] and [[PL44]]!'''''
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'''25 October 2024:''' ''Laminariawesome!'' Check out two new marine families of CBMs, '''[[CBM102]]''' and '''[[CBM103]]''', now on ''CAZypedia'' which have an ecological role in bacterial degradation of laminarin during phytoplankton blooms.  Some function as surface glycan binding proteins but others have roles in targeting their appended catalytic modules to substrate. Both pages were [[author]]ed by '''[[User:Marie-Katherin Zuehlke|Marie-Katherin Zühlke]]'''. ''Read up on these environmentally important CBMs on their respective [[CBM102]] and [[CBM103]] pages!''  
 
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'''19 July 2024:''' ''Chalk-up one more for the GTs!'' The '''[[Glycosyltransferase Family 47]]''' page joined the small group of [[Curator Approved]] [[Glycosyltransferase Families]] pages in ''CAZypedia'' today. This entry was [[author]]ed by Ph.D. students '''[[User:Daniel Tehrani|Daniel Tehrani]]''' and '''[[User:Charlie Corulli|Charlie Corulli]]''', and [[Responsible Curator|Curated]] by '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' with input from '''[https://ccrc.uga.edu/team/kelley-moremen/ Kelley Moremen]'''.  Widely represented in plants, '''[[GT47]]''' members are anomer-[[inverting]] [[glycosyltransferases]], which are involved in the biosynthesis of several cell wall matrix polysaccharides.  Representatives from mammals are involved in heparin biosynthesis.  Correspondingly, members of [[GH47]] have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides.  ''This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!''
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'''9 July 2024:''' ''Yet another new family of beta-1,2-glucan-active enzymes!'' Today, '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''' [[Curator Approved]] the '''[[Glycoside Hydrolase Family 186]]''' page by '''[[User:Sei Motouchi|Sei Motouchi]]'''. '''[[GH186]]''' is a family of anomer-[[inverting]] enzymes from bacteria, members of which are specific for beta-1,2-glucans.  Intriguingly, although some [[GH186]] members work as classic [[glycoside hydrolases]], others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack.  Also notable, [[GH186]] members appear to use an extended chain of water molecules to relay acceptor deprotonation by the [[general base]] residue, ''i.e.'' a [https://en.wikipedia.org/wiki/Grotthuss_mechanism Grotthuss mechanism]. ''Check out the '''[[GH186]]''' page to learn more about these interesting enzymes, and make sure to see the [[GH189]], [[GH144]], and [[GH162]] pages from this same group.''
  
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'''1 March 2018:''' The shortest month of the year saw four '''[[CBM]]''' families reach '''[[Curator Approved]]''' status, including two early members.  '''[[User:Harry Gilbert|Harry Gilbert]]''' with input from '''[[User:Ed Bayer|Ed Bayer]]''', who also acted as '''[[Responsible Curator]]''', authored the cellulose-binding '''[[CBM3]]''' page.  '''[[User:Harry Gilbert|Harry Gilbert]]''' and '''[[User:Claire Dumon|Claire Dumon]]''' both contributed to the xylan and glucan-binding '''[[CBM4]]''' page.  The xylan-binding '''[[CBM22]]''' page was taken on by '''[[User:Harry Gilbert|Harry Gilbert]]''' solo.  Finally, the cellulose-binding '''[[CBM78]]''' family was authored by '''[[User:Immacolata Venditto|Immacolata Venditto]]''', with '''[[User:Harry Gilbert|Harry Gilbert]]''' acting as '''[[Responsible Curator]]'''.  ''Learn more about each of these families on [[Carbohydrate Binding Module Families|their respective pages]].''
 
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'''15 February 2018:''' ''More on pectin, and also arabinan:''  '''[[User:Jonathon Briggs|Jonathon Briggs]]''' recently completed the '''[[Glycoside Hydrolase Family 147]]''' and '''[[Glycoside Hydrolase Family 146]]''' pages, which are involved in the utilization of pectin and galactan, respectively, by human gut Bacteroidetes.  Both pages were upgraded to [[Curator Approved]] status today by [[Responsible Curator]] '''[[User:Harry Gilbert|Harry Gilbert]]'''.  ''Learn more about these newly described families at [[GH146]] and [[GH147]].''
 
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'''13 February 2018:''' ''The intricacies of pectin deconstruction:'' Rhamnogalacturonan II (RGII) represents the most structurally complex plant cell wall polysaccharide currently known, the complete saccharification of which requires a battery of CAZymes.  Under the guidance of [[Responsible Curator]] '''[[User:Harry Gilbert|Harry Gilbert]]''', four new GH pages related to RGII deconstruction were [[Curator Approved]] today. Special thanks go to [[Author]]s '''[[User:Ana Luis|Ana Luis]]''' ('''[[GH106]]''', '''[[GH139]]''', and '''[[GH141]]''') and '''[[User:Didier Ndeh|Didier Ndeh]]''' ('''[[GH138]]''') for their hard work in putting these pages together. ''Learn more about the individual, specific contributions of each of these families (three of which have been recently uncovered) to microbial RGII utilization on their respective pages.''
 
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'''31 January 2018:''' ''A flurry of CBM activity in the new year:'' Over the past two weeks, ''CAZypedia'' has enjoyed the promotion of no less than ''nine(!)''  [[Carbohydrate-binding modules|Carbohydrate-binding module (CBM)]] family pages to [[Curator Approved]] status, thanks to the tenacity of [[CBM]] vanguard '''[[User:Harry Gilbert|Harry Gilbert]]''' and the keen editorial oversight of '''[[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]]'''. [[CAZypedia:Assigned_pages#Carbohydrate_Binding_Module_Families|In order of appearance]], '''[[CBM2]]''', '''[[CBM10]]''', '''[[CBM15]]''', '''[[CBM29]]''', '''[[CBM66]]''', '''[[CBM60]]''' (co-authored by '''[[User:Cedric Montanier|Cedric Montanier]]'''), '''[[CBM46]]''', and '''[[CBM35]]''' all have completed pages, as does the deleted family '''[[CBM7]]'''. These pages cover many classic CBM studies and include examples of [[Carbohydrate-binding modules#Types|type A, type B, and type C CBMs]].      ''The CBM legacy runs deep - learn more about each family on [[Carbohydrate Binding Module Families|their respective pages]].''
 
 
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'''26 November 2017:''' ''CBM #1:'' Today, [[Carbohydrate-binding modules|CBM]] pioneer '''[[User:Markus Linder|Markus Linder]]''' completed the '''[[Carbohydrate Binding Module Family 1]]''' page.  [[CBM1]] comprises the canonical fungal cellulose-binding modules (originally known as cellulose-binding ''domains''), which were first found as stable cystine-knot-containing protein fragments released by controlled proteolysis of cellulases.  The planar nature of the substrate-binding face, and linear arrangement of key aromatic residues, represent the archetype of [[Carbohydrate-binding modules|CBMs]] that mediate glycosidase targeting to crystalline polysaccharides.  Building on the original discovery of the modules now classified into [[CBM1]] in Sweden, '''[[User:Markus Linder|Markus Linder]]''' (then a Ph.D. student) and Tuula Teeri, working together across the Baltic Sea in Finland, were among the first to undertake structure-function studies and protein engineering of [[CBM1]] using modern molecular techniques in the mid- to late-1990s.  ''We're pleased to finally have this one in CAZYpedia - learn more about this seminal CBM family [[CBM1|here]].''
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'''2 May 2024:''' ''CBDs I to X... A major milestone!'' '''CBM families 1 to 10 are now complete!''' These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old-school families on their respective ''CAZypedia'' pages: '''[[CBM1]], [[CBM2]], [[CBM3]], [[CBM4]], [[CBM5]], [[CBM6]], [[CBM7]], [[CBM8]], [[CBM9]], and [[CBM10]]'''.
 
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Latest revision as of 16:03, 21 November 2024

1 November 2024: Is this a world record? Six CAZypedia families in one fell swoop! The CBM47, CBM70, CBM96, CBM105, CBM106 and PL44 CAZypedia pages are now flipped to Curator Approved status. What do these diverse families from diverse origins with diverse binding specificities have in common? Astonishingly, at least one characterized member from each family interacts with a charged glycan! Wenwen Tao authored the CBM47, CBM96 and CBM106 pages, Menghui Sun authored the CBM70 page, Guanchen Liu authored the CBM105 page and Jinhang Zhou authored the PL44 page. All this under the responsible curatorship of Yaoguang Chang. Dive into these diverse families on their respective CAZypedia pages: CBM47, CBM70, CBM96, CBM105, CBM106 and PL44!

25 October 2024: Laminariawesome! Check out two new marine families of CBMs, CBM102 and CBM103, now on CAZypedia which have an ecological role in bacterial degradation of laminarin during phytoplankton blooms. Some function as surface glycan binding proteins but others have roles in targeting their appended catalytic modules to substrate. Both pages were authored by Marie-Katherin Zühlke. Read up on these environmentally important CBMs on their respective CBM102 and CBM103 pages!

19 July 2024: Chalk-up one more for the GTs! The Glycosyltransferase Family 47 page joined the small group of Curator Approved Glycosyltransferase Families pages in CAZypedia today. This entry was authored by Ph.D. students Daniel Tehrani and Charlie Corulli, and Curated by Breeanna Urbanowicz with input from Kelley Moremen. Widely represented in plants, GT47 members are anomer-inverting glycosyltransferases, which are involved in the biosynthesis of several cell wall matrix polysaccharides. Representatives from mammals are involved in heparin biosynthesis. Correspondingly, members of GH47 have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides. This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!

9 July 2024: Yet another new family of beta-1,2-glucan-active enzymes! Today, Masahiro Nakajima Curator Approved the Glycoside Hydrolase Family 186 page by Sei Motouchi. GH186 is a family of anomer-inverting enzymes from bacteria, members of which are specific for beta-1,2-glucans. Intriguingly, although some GH186 members work as classic glycoside hydrolases, others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack. Also notable, GH186 members appear to use an extended chain of water molecules to relay acceptor deprotonation by the general base residue, i.e. a Grotthuss mechanism. Check out the GH186 page to learn more about these interesting enzymes, and make sure to see the GH189, GH144, and GH162 pages from this same group.

2 May 2024: CBDs I to X... A major milestone! CBM families 1 to 10 are now complete! These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old-school families on their respective CAZypedia pages: CBM1, CBM2, CBM3, CBM4, CBM5, CBM6, CBM7, CBM8, CBM9, and CBM10.

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