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| − | '''14 May 2019:''' ''Starch... it's not over yet:'' Two new families of starch-binding CBMs, '''[[CBM82]]''' and '''[[CBM83]]''', have joined the CAZypedia ranks. These CBMs are both found in an enormous multi-modular cell-wall anchored enzyme from a gut bacterium. The pages were both authored by '''[[User:Darrell Cockburn|Darrell Cockburn]]''' with '''[[User:Nicole Koropatkin|Nicole Koropatkin]]''' acting as responsible curator. ''Learn more about the new starch-binding '''[[CBM82]]''' and '''[[CBM83]]''' families on their respective pages''. | + | '''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page. The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''. This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''... if you dare...'' |
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| − | '''28 February 2019:''' ''CE9 is CE page #2!:'' Graduate student '''[[User:Alex Anderson|Alex Anderson]]''' has completed ''CAZypedia's'' second [[:Category:Carbohydrate Esterase Families|Carbohydrate Esterase (CE)]] family page, '''[[Carbohydrate Esterase Family 9]]''', which was [[Curator Approved]] by his supervisor '''[[User:Michael Suits|Michael Suits]]''' today. '''[[CE9]]''' enzymes are metal-dependent ''N''-acetylglucosamine 6-phosphate deacetylases that function in peptidoglycan recycling in bacteria. '''[[CE9]]''' is a huge family, currently comprising over 10,000 members (nearly all are from bacteria), which underscores their biological importance. '''[[User:Alex Anderson|Alex]]''' and '''[[User:Michael Suits|Mike]]''' completed ''CAZypedia's'' first [[:Category:Carbohydrate Esterase Families|CE family page]], [[CE4]] earlier this month, and we thank them for these seminal expansions of of our resource. ''Learn more about the structure and mechanism of metal-dependent deamidases here: [[CE9]], [[CE4]]''. | + | '''29 July 2025:''' ''[[CBM91]] is in the news!'' The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running. Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.'' |
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| − | '''22 February 2019:''' ''Starch-active LPMOs:'' '''[[User:Glyn Hemsworth|Glyn Hemsworth]]''' recently completed the '''[[Auxiliary Activity Family 13]]''' page, which was [[Curator Approved]] by [[Responsible Curator]] '''[[User:Gideon Davies|Gideon Davies]]''' today. '''[[AA13]]''' was first identified in 2014 and is notable as the first lytic polysaccharide mono-oxygenase (LPMO) family that is active on alpha-glycosidic bonds, ''viz.'' those in amylose (starch). Overall, LPMOs are an intriguing group of copper-dependent oxidases that open-up insoluble polysaccharide substrates for increased attack by [[glycoside hydrolases]]. ''Read more about '''[[AA13]]''' and related beta-glycan-active LPMOs ([[AA9]], [[AA10]], [[AA11]], [[AA14]], & AA15) on their respective [[Auxiliary Activity Families|CAZypedia pages]] and at the [http://www.cazy.org/Auxiliary-Activities.html CAZy Database].''
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| − | '''4 February 2019:''' ''CAZypedia's first CE page!'' Today [[Responsible Curator]] '''[[User:Michael Suits|Michael Suits]]''' approved the '''[[Carbohydrate Esterase Family 4]]''' page [[author]]ed by graduate student '''[[User:Alex Anderson|Alex Anderson]]''', thereby marking a new milestone ''CAZypedia's'' [[CAZypedia:History|history]]. [[:Category:Carbohydrate Esterase Families|Carbohydrate Esterases (CEs)]] catalyze the de-''O''-acylation or de-''N''-acylation of saccharides (the latter are formally amidases), and '''[[CE4]]''' contains members with either activity, ''e.g.'' acetylxylan esterases and peptidoglycan deacetylases. '''[[CE4]]''' members thus play diverse biological roles in nature. ''Learn more about the structure and mechanism of these metal-dependent de-acylases [[CE4|here]]''.
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| − | '''27 November 2018:''' ''Remember, remember... an end of November new CAZypedia CBM family page.'' The type C L-rhamnose binding [[CBM67]] family is now on-line in CAZypedia. '''[[User:Satoshi Kaneko|Satoshi Kaneko]]''' authored the page and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. ''Learn more about the structure and function of the [[CBM67]] family on its CAZypedia [[CBM67|page]]''.
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| − | '''23 November 2018:''' ''Welcome to the CAZypedia fold [[CBM49]]!'' The crystalline cellulose-binding [[CBM49]] CAZypedia page was authored by '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' and '''[[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]]'''. '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' also acted as responsible curator. There is experimental evidence that rice [[CBM49]] is cleaved post-translationally in vivo which probably plays an important role in plant growth. ''Find out more about the functionally interesting family 49 CBMs [[CBM49|here]]''.
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31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...
29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.