CAZypedia celebrates the life of Senior Curator Emeritus Harry Gilbert, a true giant in the field, who passed away in September 2025.

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We have many unassigned pages in need of Authors and Responsible Curators. See a page that's out-of-date and just needs a touch-up? - You are also welcome to become a CAZypedian. Here's how.
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Learn more about CAZypedia's misson here and in this article. Totally new to the CAZy classification? Read this first.

Difference between revisions of "Template:News"

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'''30 Apr 2012:''' ''A new cellulase fold:'' On April 27, '''[[User:Harry Gilbert|Harry Gilbert]]''' completed the '''[[Glycoside Hydrolase Family 124]]''' page here on ''CAZypedia.''  '''[[GH124]]''' is a comparatively new, but tiny, family in the CAZy classification.  This family is current comprised of only three members (2 identical sequences from 2 ''Clostridium spp.'' and 1 from ''Ruminococcus albus'') and was defined based on the demonstration of cellulase activity in one of the Clostridial members.  Remarkably, this enzyme was also shown to have a ''α''<sub>8</sub> superhelical fold, which has not been previously observed in cellulases, but is rather found in diverse lysozymes and lytic transglycosylases of [[GH23]] active on bacterial cell wall peptidoglycan.   
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'''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page. The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''.  This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''...  if you dare...''  
 
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'''09 Mar 2012:''' ''β-glucuronidases!:'' Hot on the heels of their recent seminal structural and biochemical characterization of a '''[[Glycoside Hydrolase Family 79]]''' β-glucuronidase, '''[[User:Hitomi Ichinose|Hitomi Ichinose]]''' and '''[[User:Satoshi Kaneko|Satoshi Kaneko]]''' have just completed the '''[[GH79]]''' page in ''CAZypedia''. '''[[GH79]]''' is currently a rather small family comprised of enzymes from bacteria, fungi, plants, and mammals, which remove glucuronic acid (GlcA) or 4-''O''-methyl glucuronic acid from a diversity of substrates, ranging from secondary metabolites to structural biomolecules such as proteoglycans and arabinogalactan proteins.  Click [[Glycoside Hydrolase Family 79|here]] to learn more about this interesting family!
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'''29 July 2025:''' ''[[CBM91]] is in the news!''  The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running.  Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.''
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'''11 Jan 2012:''' ''New for the new year:'' ''CAZypedia'' is proud to report that our first new page of 2012, the '''[[Glycoside Hydrolase Family 99]]''' page, has been completed by '''[[User:Spencer Williams|Spencer Williams]]''' and given [[:Category:Curator approved|Curator Approved]] status today.  This page follows the recent publication of seminal structural and mechanistic analyses by a multi-investigator team including ''CAZypedia'' Curators '''[[User:Spencer Williams|Spencer Williams]]''' and '''[[User:Gideon Davies|Gideon Davies]]''', which suggests that endo-mannosidases of this family may use an unusual mechanism involving a 1,2-anhydro-β-mannopyranose  ("sugar epoxide") intermediate to effect the release of Glc<sub>1–3</sub>-1,3-α-Man oligosaccharides during N-glycan trimming.  '''[[GH99]]''' is a small, but nonetheless important family, whose members come from both higher eukaryotes, which employ these enzymes in protein-folding quality-control, and bacteria, which are likely to use their homologues for carbohydrate scavenging in niche enviroments such as the human gut.
 
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''Also in the news:'' '''[[User:Spencer Williams|Spencer]]''' altered us to the fact that ''CAZypedia'' has clocked [[:Special:Statistics|'''one million page views''']] sometime recently.  We're not quite sure what to make of that, but it seems like a pretty neat achievement.  What is really interesting is that we are starting to see some dynamics in which pages are accessed most:  Newer pages, such as [[GH18]] (completed Oct. 2010), are becoming more popular than the very first ''CAZypedia'' page, [[GH1]] (completed May 2007).  And, some of the [[Lexicon]] pages, including those on the [[Cellulosome]] and [[Anomeric centre (alpha and beta)|anomeric configuration]] are right up there in the list.  If you like to keep score, here's a list of our most [[:Special:PopularPages|popular pages]]. Want to find out when a particular ''CAZypedia'' page was [[:Category:Curator approved|Curator Approved]]?  [[:CAZypedia:Assigned_pages|Click here]].
 
 
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Latest revision as of 10:50, 3 November 2025

31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...

29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.

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