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Difference between revisions of "Glycosyltransferase Family 138"
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== Substrate specificities == | == Substrate specificities == | ||
| − | GT138 family of glycosyltransferase is exemplified by AvrB that contains a Fido domain <cite>Peng2024, Kinch2009</cite>. AvrB is a bacterial effector from the plant pathogen ''Pseudomonas syringae''. AvrB utilizes UDP-rhamnose or dTDP-rhamnose as a co-substrate to modify the host protein RIN4 and causes the programmed cell death (namely hypersensitive response). | + | GT138 family of glycosyltransferase is exemplified by AvrB that contains a Fido domain <cite>Peng2024, Kinch2009</cite>. Proteins with Fido domain are diverse enzymes with activities of AMPylation, phosphorylation, UMPylation, and phosphocholination. AvrB is a bacterial effector from the plant pathogen ''Pseudomonas syringae''. AvrB utilizes UDP-rhamnose or dTDP-rhamnose as a co-substrate to modify the host protein RIN4 and causes the programmed cell death (namely hypersensitive response). |
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== Kinetics and Mechanism == | == Kinetics and Mechanism == | ||
Revision as of 23:08, 31 January 2025
This page is currently under construction. This means that the Responsible Curator has deemed that the page's content is not quite up to CAZypedia's standards for full public consumption. All information should be considered to be under revision and may be subject to major changes.
| Glycosyltransferase Family GT138 | |
| Clan | Fido |
| Mechanism | Inverting |
| Active site residues | Known |
| CAZy DB link | |
| https://www.cazy.org/GT138.html | |
Substrate specificities
GT138 family of glycosyltransferase is exemplified by AvrB that contains a Fido domain [1, 2]. Proteins with Fido domain are diverse enzymes with activities of AMPylation, phosphorylation, UMPylation, and phosphocholination. AvrB is a bacterial effector from the plant pathogen Pseudomonas syringae. AvrB utilizes UDP-rhamnose or dTDP-rhamnose as a co-substrate to modify the host protein RIN4 and causes the programmed cell death (namely hypersensitive response).
Kinetics and Mechanism
Content is to be added here.
Catalytic Residues
Content is to be added here.
Three-dimensional structures
Content is to be added here.
Family Firsts
- First stereochemistry determination
- Content is to be added here.
- First catalytic nucleophile identification
- Content is to be added here.
- First general acid/base residue identification
- Content is to be added here.
- First 3-D structure
- Content is to be added here.
References
- Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, and Henrissat B. (2009). The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics. Nucleic Acids Res. 2009;37(Database issue):D233-8. DOI:10.1093/nar/gkn663 |
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Davies, G.J. and Sinnott, M.L. (2008) Sorting the diverse: the sequence-based classifications of carbohydrate-active enzymes. The Biochemist, vol. 30, no. 4., pp. 26-32. DOI:10.1042/BIO03004026.