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| − | '''2 July 2014:''' ''More on the alpha-amylase clan:'' We are pleased to report that '''[[User:Stefan Janecek|Stefan Janecek]]''' has made another key contribution to ''CAZypedia'' by completing the '''[[Glycoside Hydrolase Family 77]]''' page today. '''[[GH77]]''' contains enzymes variously known as ''amylomaltases'', ''4-α-glucanotransferases'', or ''disproportionating enzymes'' (''D-enzymes'' in plants), which catalyze (1-4)-to-(1-4) transglycosylation of alpha-glucan chains and form part of the starch/glycogen debranching system. Together with [[GH13]] and [[GH70]], [[GH77]] constitutes [[Clan]] GH-H, a clan of alpha-glucan-specific enzymes united by a common (β/α)<sub>8</sub> catalytic domain fold. [[User:Stefan Janecek|Stefan]] is the founder and main organiser of ''ALAMY'' - the international symposia on the alpha-amylase enzyme family - and has been a key person in producing the [[GH13]], [[GH70]], [[GH77]] pages in ''CAZypedia''; we are especially grateful for his hard work and expertise! | + | '''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page. The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''. This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''... if you dare...'' |
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| − | ''"LysM" domains in CAZypedia:'' The cohort of [[Carbohydrate Binding Module Families]] covered in ''CAZypedia'' continues to grow with the completion of the '''[[Carbohydrate Binding Module Family 50]]''' by '''[[User:Takayuki Ohnuma|Takayuki Ohnuma]]''' and '''[[User:Toki Taira|Toki Taira]]'''. [[CBM50]] members are also known as LysM domains, which are found in a range of enzymes beyond glycoside hydrolases, including proteases, in which they are believed to facilitate targeting and degradation the bacterial cell wall. ''Read more [[Carbohydrate Binding Module Family 50|here...!]]''
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| − | '''14 May 2014:''' ''Two new CBM pages:'' We are pleased to report that '''[[User:Shinya Fushinobu|Shinya Fushinobu]]''' has produced and given [[Curator Approved]] status to two new [[CBM]] pages. '''[[Carbohydrate Binding Module Family 28]]''' contains Type B CBMs that target non-crystalline beta-glucan chains, while '''[[Carbohydrate Binding Module Family 42]]''' members are Type C CBMs that bind terminal, non-reducing-end L-arabinofuranosyl residues, as found in xylans. Both families are likely to play key role in potentiating biomass degradation by their host organisms, and are therefore relevant to related biotechnological applications. | + | '''29 July 2025:''' ''[[CBM91]] is in the news!'' The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running. Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.'' |
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| − | '''6 February 2014:''' ''Our second LPMO page:'' '''[[User:Glyn Hemsworth|Glyn Hemsworth]]''' and '''[[User:Gideon Davies|Gideon Davies]]''' have just completed the '''[[Auxiliary Activity Family 11]]''' page. '''[[AA11]]''' is a very recently discovered family of copper-dependent, lytic polysaccharide mono-oxygenases (LPMO), whose defining member catalyzes the oxidative cleavage of chitin. The LPMO field is particularly exciting and rapidly evolving, and we are proud to present the '''[[AA11]]''' page in ''CAZypedia'' so closely after the initial report on this family.
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| − | '''17 January 2014:''' ''More on CBMs:'' The '''[[Carbohydrate Binding Module Family 41]]''' page was upgraded to [[Curator Approved]] status today by '''[[User:Alicia Lammerts van Bueren|Alicia Lammerts van Bueren]]''' and '''[[User:Al Boraston|Al Boraston]]'''. '''[[CBM41]]''' is a family of alpha-glucan-binding modules, which are primarily associated with the pullulanases and debranching enzymes of [[Glycoside Hydrolase Family 13]]. ''Find out more [[Carbohydrate Binding Module Family 41|here...!]]''
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| − | '''6 January 2014:''' ''A new year, a new CBM page!'' The '''[[Carbohydrate Binding Module Family 6]]''' page was completed and given [[Curator Approved]] status today by [[Author]] and [[Responsible Curator|Curator]] '''[[User:Mirjam Czjzek|Mirjam Czjzek]]'''. '''[[CBM6]]''' was originally defined based on the observation of xylan binding, however the diversity of substrate specificities in this family has now grown to include diverse beta-glucans, chitin, and even the marine polysaccharide agarose; remarkably, some '''[[CBM6]]''' members also contain two distinct binding sites. The '''[[CBM6]]''' page is ''CAZypedia's'' second [[Carbohydrate Binding Module Families|Carbohydrate Binding Module Family]] page, and we [[Carbohydrate_Binding_Module_Families#Under_construction|look forward]] to the further expansion of this section in the new year!
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31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...
29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.