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| − | '''18 December 2013:''' ''A new mannanase page:'' Today, '''[[User:Rohan Williams|Rohan Williams]]''' and '''[[User:Spencer Williams|Spencer Williams]]''' completed the '''[[Glycoside Hydrolase Family 113]]''' page. '''[[GH113]]''' is currently a very small family (120 members) with only one characterized member, the ''Alicyclobacillus acidocaldarius'' beta(1-4)-mannanase. The seminal crystal structure of this enzyme revealed '''[[GH113]]''' to be a member of [[Clan]] GH-A. A recent publication from the '''[[User:Spencer Williams|Williams]]''' team and collaborators illuminated further details of the '''[[GH113]]''' and '''[[GH26]]''' transition states using designed inhibitor-enzyme complexes. ''Read more about this emerging family [[Glycoside Hydrolase Family 113|here]]!'' | + | '''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page. The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''. This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''... if you dare...'' |
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| − | '''New for fall 2013:''' ''The CAZy database [http://dx.doi.org/10.1093/nar/gkt1178 now presents enzyme ligands!]'' See any family's [http://www.cazy.org/GH5_structure.html "Structure" page] for examples. | + | '''29 July 2025:''' ''[[CBM91]] is in the news!'' The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running. Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.'' |
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| − | '''6 October 2013:''' '''''[[GH66]]''' page upgraded to [[Curator Approved]] status:'' Today, [[Responsible Curator]] '''[[User:Zui Fujimoto|Zui Fujimoto]]''' formally approved the '''[[Glycoside Hydrolase Family 66]]''' page, [[Author]]ed by '''[[User:Ryuichiro Suzuki|Ryuichiro Suzuki]]''', as complete and ready for public viewing. '''[[GH66]]''' is a very small family, currently containing ca. 60 members, of α(1-6)-glucan hydrolases (a.k.a. dextranases) and cyclo-isomalto-oligosaccharide glucanotransferases. Through a series of elegant studies including biochemical and crystallographic analyses, '''[[User:Zui Fujimoto|Dr. Fujimoto]]''' and his collaborators have provided direct insight into catalysis by this unique family. ''Read more about the long history of these enzymes [[Glycoside Hydrolase Family 66|here]]!''
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| − | '''30 September 2013:''' ''Our first PL page!:'' '''[[User:Wade Abbott|Wade Abbott]]''' finalized ''CAZypedia's'' first [[Polysaccharide Lyase Families|Polysaccharide Lyase Family]] page, '''[[PL2]]''', today. As with our recent foray into [[Carbohydrate Binding Module Families|CBM families]] (see our May 22 news item) the extension of ''CAZypedia'' to include the [[Polysaccharide Lyase Families|PLs]] ushers in a new phase in our development, and we are very much looking forward to the evolution of this new group of pages, spearheaded by '''[[User:Wade Abbott|Wade Abbott]]''' and '''[[User:Michael Suits|Michael Suits]]'''. ''If you are an expert on any of the [http://www.cazy.org/Polysaccharide-Lyases.html 22 PL families in the CAZy Database] and would like to contribute to ''CAZypedia'', please contact us [[Special:Contact|here]].
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| − | '''19 September 2013:''' ''We are proud to announce the completion of ''CAZypedia's'' first Auxiliary Activity (AA) Family page!'' '''[[User:Paul Harris|Paul Harris]]''', one of the founding fathers of the family previously known as [[GH61]], has composed a lucid summary of the history and state-of-the-art of '''[[Auxiliary Activity Family 9]]'''. The revelation that these enzymes are actually copper-dependent ''lytic polysaccharide mono-oxygenases'' (LPMO), and not classic cellulases as originally thought, is one of the most exciting discoveries in enzymatic biomass degradation in recent years. ''Read more about this fascinating class of enzymes on the [[Auxiliary Activity Family 9|here]], and stay tuned for forthcoming page on the closely related [[AA10]] family.
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| − | '''28 June 2013:''' ''CAZypedia'' was highlighted in a review article in ''Current Opinion in Structural Biology'' [http://dx.doi.org/10.1016/j.sbi.2013.06.001 available online today]. This review provides a succinct overview of some of the most exciting CAZyme structure-function studies in recent years, and we'd like to thank the authors, '''[[User:Shinya Fushinobu|Shinya Fushinobu]]''', Victor Alves, and '''[[User:Pedro Coutinho|Pedro Coutinho]]''', for showcasing ''CAZypedia'' as well!
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31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...
29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.